1227685-20-2

Basic information

• Product Name: (2S,4R)-1-benzyl 4-methyl 4-amino-2-methylpiperidine-1,4-dicarboxylate
• Synonyms: (2S,4R)-1-benzyl 4-methyl 4-amino-2-methylpiperidine-1,4-dicarboxylate
• CAS NO: 1227685-20-2
• Molecular Weight: 306.362
• Mol File: 1227685-20-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S,4R)-1-benzyl 4-methyl 4-amino-2-methylpiperidine-1,4-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-1-benzyl 4-methyl 4-amino-2-methylpiperidine-1,4-dicarboxylate(1227685-20-2)
• EPA Substance Registry System: (2S,4R)-1-benzyl 4-methyl 4-amino-2-methylpiperidine-1,4-dicarboxylate(1227685-20-2)

Safety Data

• Hazardous Substances Data: 1227685-20-2(Hazardous Substances Data)

Usage

Description

(2S,4R)-1-benzyl 4-methyl 4-amino-2-methylpiperidine-1,4-dicarboxylate is a chiral piperidine derivative featuring a benzyl group and two carboxylate groups. As a heterocyclic amine, it is commonly utilized in medicinal chemistry and may possess potential pharmaceutical applications due to its functional groups.
Used in Pharmaceutical Industry:
(2S,4R)-1-benzyl 4-methyl 4-amino-2-methylpiperidine-1,4-dicarboxylate is used as a potential pharmaceutical candidate for the development of new drugs, given its presence of functional groups that are often found in bioactive molecules. Further research and evaluation are required to ascertain its specific properties and potential therapeutic uses.

Upstream product

• 1227685-18-8 benzyl (2S,4S)-4-hydroxy-2-methyl-4-(trichloromethyl)-piperidine-1-carboxylate 
• 921599-74-8 benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate 
• 1227685-19-9 (2S,4R)-1-benzyl 4-methyl 4-azido-2-methylpiperidine-1,4-dicarboxylate 

Downstream Products

• 1227685-14-4 (5R,7S)-benzyl 1-(3-fluorophenyl)-7-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 
• 1227685-15-5 (5R,7S)-1-(3-fluorophenyl)-7-methyl-1,8-diazaspiro[4.5]dec-3-en-2-one 
• 1426254-45-6 (5R,7S)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-7-meth-yl-1,8-diazaspiro[4.5]dec-3-en-2-one 
• 1227685-22-4 (5R,7S)-8-benzyl 3-ethyl 7-methyl-2,4-dioxo-1,8-diazaspiro[4.5]decane-3,8-dicarboxylate 
• 1227685-23-5 (5R,7S)-benzyl 7-methyl-2,4-dioxo-1,8-diazaspiro[4.5]-decane-8-carboxylate 
• 1227685-24-6 (5R,7S)-benzyl 4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate 
• 1227685-25-7 (5R,7S)-benzyl 7-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 
• 1426254-47-8 (5R,7S)-benzyl 7-methyl-2-oxo-1-(pyridin-2-yl)-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 
• 1426254-48-9 (5R,7S)-benzyl 7-methyl-2-oxo-1-(pyrazin-2-yl)-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 
• 1426254-49-0 (5R,7S)-benzyl 7-methyl-1-(1-methyl-1H-pyrazol-4-yl)-2-oxo-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 
• 1426254-50-3 (5R,7S)-benzyl 7-methyl-2-oxo-1-(thiazol-4-yl)-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 
• 1426254-51-4 (5R,7S)-benzyl 1-(5-chloropyridin-3-yl)-7-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 
• 1227685-21-3 (2S,4R)-1-benzyl 4-methyl 4-(3-ethoxy-3-oxopropanamido)-2-methylpiperidine-1,4-dicarboxylate 
• 1338821-07-0 8-benzyl 3-methyl (5R,7S)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene-3,8-dicarboxylate 2,2-dioxide 

Relevant articles and documents

Stereoselective synthesis of spiropiperidines as BACE-1 aspartyl protease inhibitors via late stage N-arylation of a 1,8-diazaspiro[4.5]dec-3-en-2-one pharmacophore

A stereoselective synthesis of spiropiperidine compounds, exemplified by compound 1, was developed, which was based upon the late stage N-arylation of a 1,8-diazaspiro[4.5]dec-3-en-2-one pharmacophore. Previously, compound 1 was prepared in low overall yield from piperidinone 2 via the Strecker reaction. A new route was developed, which employed the stereospecific Corey-Link reaction of an enantiomerically pure trichloromethylcarbinol to give a template compound amenable to late stage N-arylation.

LACTAMS AS BETA SECRETASE INHIBITORS

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment methods of synthesis,