1227783-62-1Relevant articles and documents
Antitumor activity and COMPARE analysis of bis-indole derivatives
Andreani, Aldo,Burnelli, Silvia,Granaiola, Massimiliano,Leoni, Alberto,Locatelli, Alessandra,Morigi, Rita,Rambaldi, Mirella,Varoli, Lucilla,Landi, Laura,Prata, Cecilia,Sega, Francesco Vieceli Dalla,Caliceti, Cristiana,Shoemaker, Robert H.
experimental part, p. 3004 - 3011 (2010/07/06)
This paper reports the synthesis of new derivatives (formed by two indole systems separated by a central moiety) analogous of potent antitumor agents previously described. The activity of the bis-indoles bearing a pyridine core confirms the good result described in the previous paper and compound 4c was chosen for the first in vivo experiment (Hollow Fiber Assay). COMPARE analysis and structure-activity relationships were also considered. Contrary to data reported by other Authors, no correlations were found between antitumor activity and NQO1 induction.
