122833-23-2Relevant articles and documents
LIF/LIFR ANTAGONIST IN ONCOLOGY AND NONMALIGNANT DISEASES
-
Paragraph 0131; 0135; 0165-0168; 0270-0271, (2020/03/28)
Described herein are methods of using compounds that inhibit leukemia inhibitory factor (LIF) and/or block of the leukemia inhibitory factor receptor for treatment of liver fibrosis, proliferation of spinal tumors, and in combination therapy with an immunotherapeutic agent.
17-PHOSPHOROUS STEROID DERIVATIVES USEFUL AS PROGESTERONE RECEPTOR MODULATORS
-
Page/Page column 35, (2010/11/28)
The present invention is directed to novel 17-phosphorous steroid derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by a progesterone or glucocorticoid receptor.
Novel phosphorus-containing 17β-side chain mifepristone analogues as progesterone receptor antagonists
Jiang, Weiqin,Allan, George,Chen, Xin,Fiordeliso, James J.,Linton, Olivia,Tannenbaum, Pamela,Xu, Jun,Zhu, Peifang,Gunnet, Joseph,Demarest, Keith,Lundeen, Scott,Sui, Zhihua
, p. 949 - 954 (2007/10/03)
A novel series of steroidal compounds were designed and synthesized with various phosphorus-containing groups on the 17β-side chain as progesterone receptor antagonists. The structure-activity relationships of these compounds are discussed. Selected compo