1228354-90-2

Basic information

• Product Name: 3'-O-(4,4'-diemthoxytrityl)-5'-O-(trimethylacetyl)thymidine
• Synonyms: 3'-O-(4,4'-diemthoxytrityl)-5'-O-(trimethylacetyl)thymidine
• CAS NO: 1228354-90-2
• Molecular Weight: 628.722
• Mol File: 1228354-90-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3'-O-(4,4'-diemthoxytrityl)-5'-O-(trimethylacetyl)thymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-O-(4,4'-diemthoxytrityl)-5'-O-(trimethylacetyl)thymidine(1228354-90-2)
• EPA Substance Registry System: 3'-O-(4,4'-diemthoxytrityl)-5'-O-(trimethylacetyl)thymidine(1228354-90-2)

Safety Data

• Hazardous Substances Data: 1228354-90-2(Hazardous Substances Data)

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 40733-25-3 2'-deoxy-5'-O-pivaloylthymidine 

Downstream Products

• 76054-81-4 3'-O-(4,4'-dimethoxytrityl)thymidine 

Relevant articles and documents

A convenient protection for 4-oxopyrimidine moieties in nucleosides by the pivaloyl group

Application of the pivaloyl group as a protection for the N3 position of thymidine and uridine was investigated. Pivaloylation of thymidine is a very rapid reaction proceeding under mild conditions with excellent regioselectivity for sugar or thymine moiety, depending on the amines used. Several pivaloylated thymidine derivatives were obtained by treatment of unprotected thymidine with pivaloyl chloride under various experimental conditions. Stability of the N3-pivaloyl protecting group under basic and acidic conditions was evaluated and the conditions for its selective removal were found.