1228457-79-1

Basic information

• Product Name: ethyl (E)-2-ethyl-3,4-dioxo-5,6-diphenylhex-5-enoate
• Synonyms: ethyl (E)-2-ethyl-3,4-dioxo-5,6-diphenylhex-5-enoate
• CAS NO: 1228457-79-1
• Molecular Weight: 350.414
• Mol File: 1228457-79-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl (E)-2-ethyl-3,4-dioxo-5,6-diphenylhex-5-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (E)-2-ethyl-3,4-dioxo-5,6-diphenylhex-5-enoate(1228457-79-1)
• EPA Substance Registry System: ethyl (E)-2-ethyl-3,4-dioxo-5,6-diphenylhex-5-enoate(1228457-79-1)

Safety Data

• Hazardous Substances Data: 1228457-79-1(Hazardous Substances Data)

Upstream product

• 91-48-5 (E)-2,3-diphenylpropenoic acid 
• 58085-33-9 α-phenylcinnamoyl chloride 
• 133-13-1 ethyl diethyl malonate 
• 2048-32-0 (E)-ethyl 2,3-diphenylacrylate 
• 13702-35-7 (E)-2,3-diphenyl-propenal 
• 69923-74-6 monoethyl DL-ethyl-malonate 
• 87418-32-4 ethyl 2-(chlorocarbonyl)butanoate 
• 1228457-56-4 C₂₂H₂₇NOSi 

Downstream Products

• 1228457-93-9 ethyl (1S,5S)-1-ethyl-3-hydroxy-2-oxo-4,5-diphenylcyclopent-3-enecarboxylate 

Relevant articles and documents

Enantioselective palladium(0)-catalyzed nazarov-type cyclization

A Pd0-catalyzed asymmetric Nazarov-type cyclization is described. The optimized ligand for the reaction incorporates a weakly coordinating pyridine ring into a TADDOL-derived phosphoramidite (TADDOL=α,α,α,α-tetraaryl-1,3-dioxolane-4,5-dimethanol). The reaction leads to the formation of cyclopentenones as single diastereoisomers that incorporate two contiguous asymmetric centers, one tertiary and one an all-carbon-atom quaternary stereocenter, in high yield and optical purity. It is noteworthy that the reaction does not require that substrates should be activated by aryl substituents.