1228570-37-3 Usage
Description
(S)-2-(2-(TRIFLUOROMETHYL)PHENYL)PIPERIDINE, with the molecular formula C13H15F3N, is a piperidine derivative featuring a trifluoromethyl group attached to a phenyl ring. This chemical compound is known for its unique structure and properties, making it a valuable intermediate in the synthesis of various pharmaceuticals and agrochemicals.
Uses
Used in Pharmaceutical Industry:
(S)-2-(2-(TRIFLUOROMETHYL)PHENYL)PIPERIDINE is used as a building block for the synthesis of various pharmaceuticals. Its unique structure allows for the creation of diverse compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, (S)-2-(2-(TRIFLUOROMETHYL)PHENYL)PIPERIDINE serves as a key component in the development of new agrochemicals, contributing to the production of effective and targeted products for agricultural use.
Used in Research and Development:
(S)-2-(2-(TRIFLUOROMETHYL)PHENYL)PIPERIDINE is also utilized as a potential ligand for various biological targets in research. Its unique properties make it a promising candidate for the development of new drug candidates, further expanding its applications in the scientific community.
Check Digit Verification of cas no
The CAS Registry Mumber 1228570-37-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,8,5,7 and 0 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1228570-37:
(9*1)+(8*2)+(7*2)+(6*8)+(5*5)+(4*7)+(3*0)+(2*3)+(1*7)=153
153 % 10 = 3
So 1228570-37-3 is a valid CAS Registry Number.
1228570-37-3Relevant articles and documents
Using the competing enantioselective conversion method to assign the absolute configuration of cyclic amines with BODE’s acylation reagents
Dooley, Charles J.,Burtea, Alexander,Mitilian, Christina,Dao, Wendy T.,Qu, Bo,Salzameda, Nicholas T.,Rychnovsky, Scott D.
, p. 10750 - 10759 (2020)
The competing enantioselective conversion (CEC) method is a quick and reliable means to determine absolute configuration. Previously, Bode’s chiral acylated hydroxamic acids were used to determine the stereochemistry of primary amines, as well as cyclic and acyclic secondary amines. The enantioselective acylation has been evaluated for 4-, 5-, and 6-membered cyclic secondary amines, including medicinally relevant compounds. The limitations of the method were studied through computational analysis and experimental results. Piperidines with substituents at the 2-position did not behave well unless the axial conformer was energetically accessible, which is consistent with the transition state geometries proposed by Bode and Kozlowski. Control experiments were performed to investigate the cause of degrading selectivity under the CEC reaction conditions. The present study expands the scope of the CEC method for secondary amines and provides a better understanding of the reaction profile.
