122861-41-0 Usage
Description
Despropionyl p-Fluoro Fentanyl, also known as Despropionyl para-Fluorofentanyl (CRM), is a certified reference material that is structurally similar to known opioids. It is a metabolite of FIBF and a precursor in the synthesis of para-fluorofentanyl, as well as a potential impurity in para-fluorofentanyl preparations. Despropionyl p-Fluoro Fentanyl is characterized by its dark yellow color and low melting solid properties. It is primarily intended for research and forensic applications.
Uses
Used in Pharmaceutical Industry:
Despropionyl p-Fluoro Fentanyl is used as an intermediate in the production of fentanyl analogs for the pharmaceutical industry. Its role in the synthesis process is crucial, as it helps in the development of new and improved opioid medications with potential therapeutic benefits.
Used in Research and Development:
In the field of research and development, Despropionyl p-Fluoro Fentanyl serves as a valuable reference material for studying the structure, properties, and interactions of opioids. This helps scientists and researchers in understanding the mechanisms of action, potential side effects, and ways to improve the safety and efficacy of these drugs.
Used in Forensic Applications:
Despropionyl p-Fluoro Fentanyl is also utilized in forensic applications, where it aids in the identification and analysis of opioid-related substances in criminal investigations. Its presence as a potential impurity in para-fluorofentanyl preparations makes it a significant compound for forensic chemists to detect and analyze in cases involving opioid abuse or illegal drug manufacturing.
Check Digit Verification of cas no
The CAS Registry Mumber 122861-41-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,8,6 and 1 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 122861-41:
(8*1)+(7*2)+(6*2)+(5*8)+(4*6)+(3*1)+(2*4)+(1*1)=110
110 % 10 = 0
So 122861-41-0 is a valid CAS Registry Number.
122861-41-0Relevant articles and documents
Evaluation of agonistic activity of fluorinated and nonfluorinated fentanyl analogs on μ-opioid receptor using a cell-based assay system
Kanamori, Tatsuyuki,Okada, Yuki,Segawa, Hiroki,Yamamuro, Tadashi,Kuwayama, Kenji,Tsujikawa, Kenji,Iwata, Yuko Togawa
, p. 159 - 161 (2021/02/09)
The agonistic activity of fluorinated and nonfluorinated fentanyl analogs on μ-opioid receptor was investigated using a cell-based assay system. Based on the activity, fentanyl analogs were ranked as follows: fentanyl>isobutyrylfentanyl≈butyrylfentanyl≈methoxyacetylfentanyl>acetylfentanyl. However, among the fentanyl analogs fluorinated on the Nphenyl ring, 2-fluoro analogs and 3-fluoro analogs showed the strongest and weakest activities, respectively. These results suggest that the 2-fluorinated isomers of fentanyl analogs are more likely to cause poisoning.
Carbon-13 nuclear magnetic resonance spectra of fentanyl analogs
Brine,Boldt,Huang,Sawyer,Carroll
, p. 677 - 686 (2007/10/02)
Natural abundance carbon-13 chemical shifts are reported for the hydrochloride salts of fentanyl and fifteen analogs. The signals are assigned on the basis of chemical shift theory, SFORD multiplicities, signal intensities, comparisons with model compounds, and thiophene carbon-proton coupling constants. In addition to its forensic value, the data suggest that the solution conformations of the analogs are similar to that of fentanyl hydrochloride.
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