1228692-32-7Relevant articles and documents
Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists
Guo, Cheng,Guzzo, Peter R.,Hadden, Mark,Sargent, Bruce J.,Yet, Larry,Kan, Yanqing,Palyha, Oksana,Kelly, Theresa M.,Guan, Xiaoming,Rosko, Kim,Gagen, Karen,Metzger, Joseph M.,Dragovic, Jasminka,Lyons, Kathryn,Lin, Linus S.,Nargund, Ravi P.
scheme or table, p. 2785 - 2789 (2010/07/08)
The original structure of a high-throughput screening hit obtained from an external vendor was revised based on multiple NMR studies. The active compound was re-synthesized via a novel route and its structure and biological activity as a BRS-3 agonist were unambiguously confirmed. Multi-gram quantities of the hit were prepared for pharmacokinetic and efficacy studies. The synthetic strategy allowed for the preparation of multiple analogs for SAR exploration.
