1228801-86-2

Basic information

• Product Name: rac-2-(4-fluorophenyl)-4-methyloxazol-5(4H)-one
• Synonyms: rac-2-(4-fluorophenyl)-4-methyloxazol-5(4H)-one
• CAS NO: 1228801-86-2
• Molecular Weight: 193.177
• Mol File: 1228801-86-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: rac-2-(4-fluorophenyl)-4-methyloxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: rac-2-(4-fluorophenyl)-4-methyloxazol-5(4H)-one(1228801-86-2)
• EPA Substance Registry System: rac-2-(4-fluorophenyl)-4-methyloxazol-5(4H)-one(1228801-86-2)

Safety Data

• Hazardous Substances Data: 1228801-86-2(Hazardous Substances Data)

Upstream product

• 302-72-7 rac-Ala-OH 
• 25569-77-1 4-fluorobenzoic anhydride 
• 1396964-93-4 rac-ethyl 2-(4-fluorobenzamido)propanoate 
• 451-28-5 rac-2-(4-fluorobenzamido)propanoic acid 

Downstream Products

• 1228801-87-3 1,2-bis(ethoxycarbonyl)-5-(4-fluorophenyl)-3-methyl-2,3-dihydro-1H-1,2,4-triazole-3-carboxylic acid 
• 1474012-79-7 C₁₄H₁₁FN₂O₂ 
• 1153734-59-8 ethyl 2-(4-fluorophenyl)-4-methyl-1H-imidazole-5-carboxylate 

Relevant articles and documents

Group-Assisted Purification Chemistry for Asymmetric Mannich-type Reaction of Chiral N-Phosphonyl Imines with Azlactones Leading to Syntheses of α-Quaternary α,β-Diamino Acid Derivatives ?

An asymmetric Mannich-type reaction between chiral N-phosphonyl imines and azlactones [oxazol-5(4H)-ones] has been established under convenient conditions at room temperature. The reaction was performed without using any bases, additives, or catalysts to achieve up to excellent chemical yields and diastereoselectivity for 32 examples. The α-quaternary syn-α,β-diamino acid products were purified simply by washing the crude mixtures with cosolvents, following the group-assisted purification chemistry/technology, without involving traditional chromatography or recrystallization methods. The auxiliary can be readily removed and recycled for reuse. The absolute configuration was unambiguously assigned by X-ray structural analysis.

Synthesis of di- and tri-substituted imidazole-4-carboxylates via PBu3-mediated [3+2] cycloaddition

Some new di- and trisubstituted imidazole-4-carboxylates were prepared from amidoacetic acids 3 in the present report. The key step to establish such imidazole- 4-carboxylates stemmed from the PBu3-mediated [3+2] cycloaddition between in situ-generated Δ2-oxazolinone 4 and ethyl cyanoformate6. Our results indicated that trisubstituted imidazoles 7-20 were afforded in better yields than those of disubstituted imidazoles 21-27. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications1 to view the free supplemental file. Copyright Taylor & Francis Group, LLC.

Synthesis of 1,2,4-Triazolines and triazoles utilizing oxazolones

We describe herein a convenient method for the synthesis of 1,2,4-triazolines using oxazolones and azodicarboxylates. Subsequent treatment of these 1,2,4-triazolines with NaOH provides efficient access to the corresponding triazoles.