1228836-12-1

Basic information

• Product Name: 4-[[(4-aminotetrahydro-2H-pyran-4-yl)methyl]amino]-3-nitrobenzenesulfonamide
• Synonyms: 4-[[(4-aminotetrahydro-2H-pyran-4-yl)methyl]amino]-3-nitrobenzenesulfonamide
• CAS NO: 1228836-12-1
• Molecular Weight: 0
• Mol File: 1228836-12-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-[[(4-aminotetrahydro-2H-pyran-4-yl)methyl]amino]-3-nitrobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[[(4-aminotetrahydro-2H-pyran-4-yl)methyl]amino]-3-nitrobenzenesulfonamide(1228836-12-1)
• EPA Substance Registry System: 4-[[(4-aminotetrahydro-2H-pyran-4-yl)methyl]amino]-3-nitrobenzenesulfonamide(1228836-12-1)

Safety Data

• Hazardous Substances Data: 1228836-12-1(Hazardous Substances Data)

Upstream product

• 50289-16-2 4-(aminomethyl)tetrahydro-2H-pyran-4-amine 
• 97-09-6 4-Chloro-3-nitrobenzenesulfonamide 

Relevant articles and documents

Solid dispersions containing an apoptosis-inducing agent

A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.