1229454-43-6

Basic information

• Product Name: 2-fluoro-3-benzyloxy-6-nitrotoluene
• Synonyms: 2-fluoro-3-benzyloxy-6-nitrotoluene
• CAS NO: 1229454-43-6
• Molecular Weight: 261.253
• Mol File: 1229454-43-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-fluoro-3-benzyloxy-6-nitrotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-3-benzyloxy-6-nitrotoluene(1229454-43-6)
• EPA Substance Registry System: 2-fluoro-3-benzyloxy-6-nitrotoluene(1229454-43-6)

Safety Data

• Hazardous Substances Data: 1229454-43-6(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 914348-35-9 1,2-difluoro-3-methyl-4-nitrobenzene 

Downstream Products

• 288386-04-9 4-fluoro-1H-indol-5-ol 
• 288385-88-6 4-fluoro-2-methyl-1H-indol-5-ol 

Relevant articles and documents

Preparation method of 4-fluoro-5-hydroxy-2-methyl-1H-indole

The invention provides a preparation method of 4-fluoro-5-hydroxy-2-methyl-1H-indole. The preparation method comprises the steps that 2-fluoro-3-halo-6-nitrotoluene is used as a raw material and subjected to a substitution reaction with alcohol to prepare 2-fluoro-3-GO substituent-6-nitrotoluene, then 2-fluoro-3-GO substituent-6-nitrotoluene is subjected to a condensation reaction with trimethyl orthoacetate or triethyl orthoacetate to obtain 1-(2-fluoro-3-GO substituent-6-nitrophenyl)-2-alkoxy propylene, and then 1-(2-fluoro-3-GO substituent-6-nitrophenyl)-2-alkoxy propylene is further subjected to a reduction-cyclization reaction to obtain 4-fluoro-5-hydroxy-2-methyl-1H-indole. The preparation method is safe and green, simple in operation, low in cost, high in selectivity and high in yield and purity of a final product.