122949-20-6Relevant articles and documents
Carbonylative C-C bond activation of aminocyclopropanes using a temporary directing group strategy
Wang, Gang-Wei,Sokolova, Olga O.,Young, Tom. A.,Christodoulou, Ektor M. S.,Butts, Craig P.,Bower, John F.
, p. 19006 - 19011 (2020)
Temporary directing groups (TDGs) underpin a range of C-C bond activation methodologies; however, the use of TDGs for the regiocontrolled activation of cyclopropane C-C bonds is underdeveloped. In this report, we show how an unusual ring contraction process can be harnessed for TDG-based carbonylative C-C bond activations of cyclopropanes. The method involves the transient installation of an isocyanate-derived TDG, rather than relying on carbonyl condensation events as used in previous TDG-enabled C-C bond activations.
GENERATION AND CYCLIZATION OF NITRILIUM IONS FROM AMIDES. ASYMMETRIC SYNTHESIS OF FUSED AZABICYCLICS
Gawley, Robert E.,Chemburkar, Sanjay
, p. 2071 - 2074 (2007/10/02)
Treatment of 2o amides with PPSE affords nitrilium ions which may be cyclized onto appropriate terminators.The conditions are compatible with esters in the molecule, and further elaboration to pyrrolizidine and indolizidine rings is possible vi
