1229576-22-0

Basic information

• Product Name: C₂₃H₂₉NO₅
• CAS NO: 1229576-22-0
• Molecular Weight: 399.487
• Mol File: 1229576-22-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₉NO₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₉NO₅(1229576-22-0)
• EPA Substance Registry System: C₂₃H₂₉NO₅(1229576-22-0)

Safety Data

• Hazardous Substances Data: 1229576-22-0(Hazardous Substances Data)

Upstream product

• 29921-57-1 isopropyl 2-bromoacetate 
• 1229575-44-3 C₁₈H₂₁NO₃ 

Relevant articles and documents

Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors

BACE-1 has been shown to be an attractive therapeutic target in Alzheimer's disease (AD). Using a 1,4-dihydropyridine (DHP) scaffold, we synthesized new inhibitors of BACE-1 by modifying the known BACE inhibitor 2 containing a hydroxyethylamine (HEA) motif. Using structure-based drug design based on computer-aided molecular docking, the isophthalamide ring of 2 was replaced with a 1,4-dihydropyridine ring as a brain-targeting strategy. Several of the new dihydropyridine derivatives were synthesized and their BACE-1-inhibitory activities were evaluated using a cell-based, reporter gene assay system that measures the cleavage of alkaline phosphatase (AP)-APP fusion protein by BACE-1. Most of the 1,4-DHP analogs showed BACE-1-inhibitory activities with IC50 values in the range 8-30?μM, suggesting that the 1,4-DHP skeleton may be utilized to develop brain-targeting BACE-1 inhibitors.