123-47-7

Basic information

• Product Name: 2-HYDROXY-N,N,N,N',N',N'-HEXAMETHYL-1,3-PROPANE DIAMINIUM DI IODIDE
• Synonyms: PROLONIUM IODIDE;Entodon;prolonium;HEXAMETHYLDIAMINOISOPROPANOL DIIODIDE;2-HYDROXY-N,N,N,N',N',N'-HEXAMETHYL-1,3-PROPANE DIAMINIUM DI IODIDE;N,N-(2-hydroxytrimethylene)bis(trimethylammonium) diiodide;HYDROXYPROPYL BISTRIMONIUM DIIODIDE;Iodisan
• CAS NO: 123-47-7
• Molecular Formula: C₉H₂₄N₂O*2I
• Molecular Weight: 430.11
• EINECS: 204-630-9
• Mol File: 123-47-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: ~275° with decompn
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-HYDROXY-N,N,N,N',N',N'-HEXAMETHYL-1,3-PROPANE DIAMINIUM DI IODIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-N,N,N,N',N',N'-HEXAMETHYL-1,3-PROPANE DIAMINIUM DI IODIDE(123-47-7)
• EPA Substance Registry System: 2-HYDROXY-N,N,N,N',N',N'-HEXAMETHYL-1,3-PROPANE DIAMINIUM DI IODIDE(123-47-7)

Safety Data

• Hazardous Substances Data: 123-47-7(Hazardous Substances Data)

Usage

Description

2-HYDROXY-N,N,N,N',N',N'-HEXAMETHYL-1,3-PROPANE DIAMINIUM DI IODIDE, also known as Entodon, is a white, crystalline solid with unique chemical properties. It is freely soluble in water, slightly soluble in alcohol, and insoluble in ether and acetone. 2-HYDROXY-N,N,N,N',N',N'-HEXAMETHYL-1,3-PROPANE DIAMINIUM DI IODIDE is primarily used in the medical field for iodine therapy, making it a valuable pharmaceutical agent.

Uses

Used in Medicine:
2-HYDROXY-N,N,N,N',N',N'-HEXAMETHYL-1,3-PROPANE DIAMINIUM DI IODIDE is used as a therapeutic agent for iodine therapy to treat various medical conditions that benefit from the administration of iodine.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-HYDROXY-N,N,N,N',N',N'-HEXAMETHYL-1,3-PROPANE DIAMINIUM DI IODIDE is used as an active pharmaceutical ingredient for the development of medications that require iodine supplementation or treatment. Its unique solubility properties make it suitable for formulation in various dosage forms, such as tablets, capsules, and solutions.
Brand Name:
Entodon (Sterling Winthrop) is the brand name under which 2-HYDROXY-N,N,N,N',N',N'-HEXAMETHYL-1,3-PROPANE DIAMINIUM DI IODIDE is marketed, making it easily recognizable and accessible to healthcare professionals and patients.

InChI:InChI=1/C9H24N2O.2HI/c1-10(2,3)7-9(12)8-11(4,5)6;;/h9,12H,7-8H2,1-6H3;2*1H/q+2;;/p-2

Synthetic route

ethanol (64-17-5) + N,N,N,N',N',N'-hexamethyl-1,3-diammonium-2-propanol diiodide (123-47-7) + trimethylamine (75-50-3) → 1,3-bis-(dimethylamino)propan-2-ol (5966-51-8) + tertamethylammonium iodide (75-58-1)

Conditions	Yield
at 100℃;

potassium tetraiodobismuthate(III) (39775-75-2) + N,N,N,N',N',N'-hexamethyl-1,3-diammonium-2-propanol diiodide (123-47-7) → CH(OH)(CH2N(CH3)3)2(2+)*2I(1-)*2BiI3=CH(OH)(CH2N(CH3)3I)2*2BiI3

Conditions	Yield
In hydrogenchloride addition of K(BiI4) to an aq. hydrochloric solution of the organic compound;; washing with alcohol, drying at 40°C;;

Downstream Products

• 5966-51-8 1,3-bis-(dimethylamino)propan-2-ol 
• 75-58-1 tertamethylammonium iodide