123018-62-2

Basic information

• Product Name: 4,4-DI-N-PROPYLCYCLOHEXANONE
• Synonyms: 4,4-DIPROPYLCYCLOHEXAN-1-ONE;4,4-DIPROPYLCYCLOHEXANONE;4,4-DI-N-PROPYLCYCLOHEXANONE;4-DIPROPYLCYCLOHEXANONE
• CAS NO: 123018-62-2
• Molecular Formula: C₁₂H₂₂O
• Molecular Weight: 182.3
• Product Categories: Miscellaneous Reagents;Ring Systems;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 123018-62-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 57-60°C/0.5 mm
• Flash Point: 95.6°C
• Appearance: /
• Density: 0.87g/cm³
• Vapor Pressure: 0.027mmHg at 25°C
• Refractive Index: 1.443
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Ethyl Acetate
• CAS DataBase Reference: 4,4-DI-N-PROPYLCYCLOHEXANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-DI-N-PROPYLCYCLOHEXANONE(123018-62-2)
• EPA Substance Registry System: 4,4-DI-N-PROPYLCYCLOHEXANONE(123018-62-2)

Safety Data

• Hazardous Substances Data: 123018-62-2(Hazardous Substances Data)

Usage

Description

4,4-Di-N-propylcyclohexanone is a clear, colorless liquid with unique chemical properties that make it a valuable compound in the pharmaceutical industry. It is primarily utilized in the synthesis of N-substituted phenylacetamide derivatives, which are known for their therapeutic effects on pain and inflammation.

Uses

Used in Pharmaceutical Industry:
4,4-Di-N-propylcyclohexanone is used as a key intermediate compound for the preparation of N-substituted phenylacetamide derivatives. These derivatives serve as therapeutic agents for the treatment of pain and inflammation, making them essential in the development of medications aimed at alleviating these conditions.

InChI:InChI=1/C12H22O/c1-3-7-12(8-4-2)9-5-11(13)6-10-12/h3-10H2,1-2H3

Upstream product

• 60729-41-1 4,4-dipropylcyclohex-2-en-1-one 

Downstream Products

• 1314090-60-2 N-(4,4-dipropyl-cyclohexylidene)-N'-pyridin-4-ylhydrazine 
• 913747-65-6 4,4-dipropylcyclohexanoneoxime 
• 123018-48-4 SKandF 106610 
• 123018-47-3 atiprimod 
• 123018-34-8 N,N-dimethyl-8,8-dipropyl-2-azaspiro [4,5] decane-2-propanamine dihydrochloride 
• 948552-26-9 Cyano-(1-cyano-4,4-dipropyl-cyclohexyl)-acetic acid ethyl ester 
• 130065-94-0 4,4-dipropyl-1-carboxycyclohexane-1-acetic acid 
• 123018-68-8 (1-Carboxymethyl-4,4-dipropyl-cyclohexyl)-acetic acid 
• 123018-64-4 4,4-dipropyl-1-carboxycyclohexane-1-acetic acid anhydride 
• 130065-93-9 ethyl α-cyano-α-(4,4-dipropylcyclohexylidene)acetate 

Relevant articles and documents

N-SUBSTITUTED PHENYLACETAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

A compound represented by the formula: (I) wherein R1 represents a methoxy group, a hydroxyl group or a hydrogen atom; R2 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkylcarbonyl group or an arylcarbonyl group; and D represents a group represented by the formula (A), (B) or (C) below. (A) (B) (C) This compound is useful as a therapeutic agent for a pain or inflammation induced by any one of various morbid conditions such as neuropathic pain, rheumatoid arthritis and osteoarthritis.

Antiarthritic and suppressor cell inducing activity of azaspiranes: Structure-function relationships of a novel class of immunomodulatory agents

Spirogermanium (1;8,8-diethyl-N,N-dimethyl-2-aza-8-germaspiro[4.5]decane-2-propanamin e dihydrochloride) is a potent cytotoxic agent in vitro which has demonstrated limited activity in experimental animal tumor models. Subsequently, it has been reported that spirogermanium has antiarthritic and suppressor cell-inducing activity. We have synthesized a series of substituted 8-hetero-2-azaspiro[4.5]decane and 9-hetero-3-azaspiro[5.5]undecane analogues of spirogermanium to identify the heteroatom requirements for in vivo antiarthritic and suppressor cell-inducing activity. This structure-activity relationship study has identified that appropriately substituted silicon and carbon analogues of spirogermanium retain both antiarthritic and immunosuppressive activity, with the 8,8-dipropyl (carbon) analogue being among the most active. Following the identification of N,N-dimethyl-8,8-dipropyl-2-azaspiro[4,5]decane-2-propanamine dihydrochloride (9) as more active analogue than spirogermanium, a series of 8,8-dipropyl analogues with various amine substituents were synthesized. A number of these analogues had activity similar to that of 9. A correlation between activity in the adjuvant arthritic rat and the ability to induce suppressor cells (r = 0.894, p0.001) suggests an association between the two pharmacologic effects. While the precise biochemical mechanism(s) for the pharmacological activity is unclear, these data suggest that compounds within this series, e.g., N,N-dimethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine dihydrochloride, may provide effective therapy in diseases of autoimmune origin and/or the prevention of rejection in tissue transplantation.