123043-88-9

Basic information

• Product Name: 5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione
• CAS NO: 123043-88-9
• Molecular Weight: 276.359
• Mol File: 123043-88-9.mol
• Article Data: 117

Chemical Properties

• CAS DataBase Reference: 5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione(123043-88-9)
• EPA Substance Registry System: 5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione(123043-88-9)

Safety Data

• Hazardous Substances Data: 123043-88-9(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 100-52-7 benzaldehyde 
• 17356-08-0 thiourea 
• 123044-09-7 2-(2-ethoxycarbonylethyl)thio-6-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester 
• 199917-20-9 4-hydroxy-4-methyl-6-phenyl-5-ethoxycarbonylhexahydropyrimidine-2-thione 
• 31771-33-2 2-phenyl-4,4,6-trimethyltetrahydro-(2H)-1,3-oxazine 
• 15802-62-7 (Z)-ethyl 2-benzylidenacetoacetate 
• 37622-16-5 thiouronium hydrogensulfate 
• 123044-13-3 ethyl 2-amino-4-methyl-6-phenyl-6H-1,3-thiazine-5-carboxylate 
• 40734-80-3 N-[(phenyl)(tosyl)methyl]thiourea 
• 4756-05-2 thioacetone 
• 581-55-5 benzylidene 1,1-diacetate 
• 100-51-6 benzyl alcohol 
• 1147550-11-5 ammonium thiocyanate 

Downstream Products

• 1117816-28-0 C₃₀H₂₃ClN₄O₄ 
• 1100140-95-1 3-phenyl-1-thioxo-1,2,3,5,6,7-hexahydropyrrolo[1,2-c]pyrimidine-4-carboxylic acid ethyl ester 
• 1149335-18-1 5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-(4-cyanophenyl)vinyl)-1,4-dihydropyrimidine 
• 1149335-23-8 5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-(2,5-dimethoxyphenyl)vinyl)-1,4-dihydropyrimidine 
• 1149335-17-0 5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-biphenylvinyl)-1,4-dihydropyrimidine 
• 1149335-28-3 C₂₂H₂₂N₂O₃S 
• 1149335-15-8 5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine 
• 1149335-22-7 5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-(4-chlorophenyl)vinyl)-1,4-dihydropyrimidine 
• 1149335-16-9 5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-(4-bromophenyl)vinyl)-1,4-dihydropyrimidine 
• 1149335-19-2 5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-(3-nitrophenyl)vinyl)-1,4-dihydropyrimidine 
• 1149335-21-6 5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-(2-naphthyl)vinyl)-1,4-dihydropyrimidine 
• 1149335-24-9 5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-(4-methoxyphenyl)vinyl)-1,4-dihydropyrimidine 
• 1149335-20-5 5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-(3-bromophenyl)vinyl)-1,4-dihydropyrimidine 
• 1160739-89-8 ethyl 6-methyl-4-phenyl-2-(2-methylprop-1-enyl)-1,4-dihydropyrimidine-5-carboxylate 

Relevant articles and documents

One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones using lanthanum chloride as a catalyst

An efficient synthesis of 3,4-dihydropyrimidinones using lanthanum chloride heptahydrate as a catalyst from an aldehyde, β-keto ester and urea or thiourea in ethanol is described. Compared to the classical Biginelli reaction conditions, this new method co

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Iodine catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones and thiones: A simple and efficient procedure for the Biginelli reaction

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Polyvinylsulfonic acid: An efficient, water-soluble and reusable bronsted acid catalyst for the three-component synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones in water and ethanol

A facile and environmentally benign protocol has been developed for the one-pot three-component synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones from the cyclocondensation reaction of aldehyde, ethyl acetoacetate (β-dicarbonyl compound) and urea or th

Efficient and Green Microwave-Assisted Multicomponent Biginelli Reaction for the Synthesis of Dihydropyrimidinones Catalyzed by Heteropolyanion-Based Ionic Liquids under Solvent-Free Conditions

An efficient and green route for the synthesis of dihydropyrimidinones via microwave-assisted Biginelli reaction catalyzed by 3 mol% of heteropolyanion-based ionic liquids under solvent-free conditions has been reported. The practical reaction was found t

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The host-guest complex between polyethylene glycol and thiourea dioxide (PEG.TUD) was prepared via different approaches involving co-crystallization method and by a chemical reaction. The resulting PEG.TUD complex was found to be very active and recyclabl

Polymeric imidazolium ionic liquid-tagged manganese Schiff base complex: an efficient catalyst for the Biginelli reaction

Abstract: In this study, a new organometallic catalyst including polymeric imidazolium ionic liquid-functionalized Mn(III) Schiff base complex (PIL-SB-Mn(III)) was prepared and characterized using various analyses like FTIR, H-NMR, FE-SEM, EDX, TGA, and ICP-OES. Then, the applications of catalyst were tested in the synthesis of 3,4-dihydropyrimidine-2(1H)-one/thiones under solvent-free conditions. This polymeric ionic liquid catalyst can carry out the Biginelli reaction in less than an hour in good to excellent yields. The recovered catalyst has been characterized by FTIR and EDX analyses; heterogeneous nature of this catalyst has been confirmed successfully. Graphic abstract: [Figure not available: see fulltext.].

An efficient one-pot synthesis of dihydropyrimidinones by a samarium diiodide catalyzed biginelli reaction under solvent-free conditions

The Biginelli reaction, a one-pot condensation of aldehydes, urea or thiourea, and β-dicarbonyl compounds, is efficiently catalyzed by samarium diiodide. The biologically active dihydropyrimidinones are easily synthesized in moderate to excellent yields u

A Novel Cu-catalysed Three-component One-pot Synthesis of Dihydropyrimidin-2(1H)-ones Using Microwaves under Solvent-free Conditions

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