123044-27-9

Basic information

• Product Name: ethyl 1,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS NO: 123044-27-9
• Molecular Weight: 274.32
• Mol File: 123044-27-9.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: ethyl 1,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate(123044-27-9)
• EPA Substance Registry System: ethyl 1,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate(123044-27-9)

Safety Data

• Hazardous Substances Data: 123044-27-9(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 100-52-7 benzaldehyde 
• 598-50-5 N-Methylurea 
• 615-79-2 ethyl 2,4-diketopentanoate 
• 930288-11-2 1,6-dimethyl-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid ethyl ester 
• 1078-58-6 diphenylzinc 
• 123237-03-6 ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate 
• 74-88-4 methyl iodide 
• 108-86-1 bromobenzene 
• 3693-54-7 diethyl N,N'-benzylidenebis(carbamate) 
• 591-51-5 phenyllithium 
• 30122-00-0 α-chloro-benzylisocyanate 
• 21759-71-7 ethyl N-methyl-β-aminocrotonate 
• 67-56-1 methanol 

Downstream Products

• 82447-97-0 1,6-dimethyl-2-oxo-3-acetyl-4-phenyl-5-ethoxycarbonyl-1,2,3,4-tetrahydropyrimidine 
• 123044-15-5 1,6-dimethyl-3-formyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester 
• 113271-92-4 1-methyl-2-oxo-4-phenyl-5-chloro-5-ethoxycarbonyl-6-chloromethylenehexahydropyrimidine 
• 113271-91-3 1-methyl-2-oxo-4-phenyl-5-ethoxycarbonyl-6-dichloromethyl-1,2,3,4-tetrahydropyrimidine 
• 113271-93-5 1-methyl-2-oxo-4-phenyl-5-chloro-5-ethoxycarbonyl-6-dichloromethylenehexahydropyrimidine 
• 82447-98-1 3-Methyl-2-oxo-6-phenyl-2,3-dihydro-pyrimidine-4,5-dicarboxylic acid 5-ethyl ester 
• 189374-16-1 3-(2-Methoxycarbonyl-acetyl)-1,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 
• 95928-50-0 1,6-dimethyl-2-oxo-4-phenyl-1,2-dihydropyrimidine-5-carboxylic acid ethyl ester 
• 1388627-82-4 (4R)-5-ethoxycarbonyl-1,6-dimethyl-3-[(S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-phenylpropionyl]-4-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 1388627-81-3 (4S)-5-ethoxycarbonyl-1,6-dimethyl-3-[(S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-phenylpropionyl]-4-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 189374-03-6 3-(2-Diazo-2-methoxycarbonyl-acetyl)-1,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 
• 189374-05-8 6-[(ethyloxy)carbonyl]-7,8-dimethyl-2-[(methyloxy)carbonyl]-5-phenyl-5H,8H-[1,3]oxazolo[3,2-a]pyrimidin-4-ium-3-olate 
• 91047-69-7 ethyl 1-methyl-2-oxo-4-phenyl-1,2-dihydro-5-pyrimidinecarboxylate 

Relevant articles and documents

Expedient Synthesis of Biginelli-Type Dihydropyrimidinones Using α-(Benzotriazolyl)alkyl Urea Derivatives

Reaction of readily available α-(benzotriazolyl)alkyl urea derivatives (derived from aromatic, heteroaromatic, and aliphatic aldehydes) with β-keto esters resulted in 3,4-dihydropyrimidin-2(1H)-ones in good to excellent yields.

A highly regio- and chemoselective addition of carbon nucleophiles to pyrimidinones. A new route to C4 elaborated Biginelli compounds

Ethyl 6-methyl-pyrimidine-2-one-5-carboxylates react with C-nucleophiles in a diversity oriented synthetic sequence to afford C4 substituted congeners of medicinally potent Biginelli dihydropyrimidinones, in a highly regioselective manner.

Enantioselective N-Acylation of Biginelli Dihydropyrimidines by Oxidative NHC Catalysis

The oxidative N-acylation reaction of 3,4-dihydropyrimidin-2-(1H)-ones (DHPMs) with enals and N-heterocyclic carbene (NHC) catalysts is described. The reaction proceeds in the presence of quinone oxidant without additional acyl transfer agents and in the

Cerous p-Toluenesulfonate as an Efficient and Recyclable Catalyst for the Synthesis of N1-Substituted-4-aryl-3,4-dihydropyrimidin-2(1H)-ones

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(C5H6N4O)(C5H5N4O)3(C5H4N4O)[Bi2Cl11]Cl2 as a simple and efficient catalyst in Biginelli reaction

A highly efficient and facile procedure for the one-pot three-component synthesis of 3,4-dihydropyrimidin-2-(1H)ones/thiones from the one-pot condensation of aldehyde, β-dicarbonyl compound and urea/thiourea was developed. The methodology is applicable to