1230558-91-4Relevant articles and documents
Piperazine sulfonamide BACE1 inhibitors: Design, synthesis, and in vivo characterization
Cumming, Jared,Babu, Suresh,Huang, Ying,Carrol, Carolyn,Chen, Xia,Favreau, Leonard,Greenlee, William,Guo, Tao,Kennedy, Matthew,Kuvelkar, Reshma,Le, Thuy,Li, Guoqing,McHugh, Nansie,Orth, Peter,Ozgur, Lynne,Parker, Eric,Saionz, Kurt,Stamford, Andrew,Strickland, Corey,Tadesse, Dawit,Voigt, Johannes,Zhang, Lili,Zhang, Qi
, p. 2837 - 2842 (2010)
With collaboration between chemistry, X-ray crystallography, and molecular modeling, we designed and synthesized a series of novel piperazine sulfonamide BACE1 inhibitors. Iterative exploration of the non-prime side and S2′ sub-pocket of the enzyme culmin
