1230788-53-0

Basic information

• Product Name: N-(1-(3-aminophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide
• Synonyms: N-(1-(3-aminophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide
• CAS NO: 1230788-53-0
• Molecular Weight: 328.373
• Mol File: 1230788-53-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(1-(3-aminophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-(3-aminophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide(1230788-53-0)
• EPA Substance Registry System: N-(1-(3-aminophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide(1230788-53-0)

Safety Data

• Hazardous Substances Data: 1230788-53-0(Hazardous Substances Data)

Upstream product

• 55052-28-3 4-chloro-7-azaindole 
• 271-63-6 7-Azaindole 
• 74420-18-1 7-Hydroxy-1H-pyrrolo<2,3-b>pyridinium m-chlorobenzoate 
• 99-09-2 3-nitro-aniline 
• 6980-11-6 7-chloro-3H-imidazo<4,5-b>pyridine 
• 273-21-2 3H-imidazo[4,5-b]pyridine 
• 1230788-50-7 4-amino-1-(3-nitrophenyl)-1H-pyrrolo[3,2-c]pyridine hydrochloride 
• 1230788-51-8 N-(1-(3-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide 

Downstream Products

• 1374585-40-6 C₃₂H₂₃F₃N₆O₂ 
• 1374585-45-1 C₂₅H₂₂F₃N₅O₂ 
• 1384513-33-0 C₃₅H₃₄F₃N₇O₂ 
• 1374585-41-7 C₂₇H₁₈Cl₂N₄O₂ 
• 1374585-38-2 C₂₈H₁₉F₃N₄O₂ 
• 1374585-44-0 C₂₁H₁₅F₃N₄O 
• 1374585-37-1 C₂₈H₁₈ClF₃N₄O₂ 
• 1374585-34-8 C₂₇H₁₉Cl₂N₅O₂ 
• 1374585-35-9 C₂₉H₁₉F₆N₅O₂ 
• 1374585-43-9 C₂₀H₁₅Cl₂N₅O 
• 1374585-33-7 C₂₇H₁₉Cl₂N₅O₂ 
• 1374585-42-8 C₂₁H₁₆F₃N₅O 
• 1374585-39-3 C₃₂H₂₆F₃N₅O₃ 

Relevant articles and documents

Pyrrolo[3,2-c]pyridine derivatives with potential inhibitory effect against FMS kinase: in vitro biological studies

A series of eighteen pyrrolo[3,2-c]pyridine derivatives were tested for inhibitory effect against FMS kinase. Compounds 1e and 1r were the most potent among all the other tested analogues (IC50 = 60 nM and 30 nM, respectively). They were 1.6 and 3.2 times, respectively, more potent than our lead compound, KIST101029 (IC50 = 96 nM). Compound 1r was tested over a panel of 40 kinases including FMS, and exerted selectivity against FMS kinase. It was further tested against bone marrow-derived macrophages (BMDM) and its IC50 was 84 nM (2.32-fold more potent than KIST101029 (IC50 = 195 nM)). Compound 1r was also tested for antiproliferative activity against a panel of six ovarian, two prostate, and five breast cancer cell lines, and its IC50 values ranged from 0.15–1.78 μM. It possesses also the merit of selectivity towards cancer cells than normal fibroblasts.

Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. Part 2

A new series of diarylureas and diarylamides possessing 1H-pyrrolo[3,2-c]pyridine scaffold was designed and synthesized. Their in vitro antiproliferative activities against A375P human melanoma cell line and NCI-9 human melanoma cell line panel were tested. All the target compounds, except three amino derivatives 8g, h and 9h, demonstrated superior potencies against A375P to Sorafenib. In addition, compounds 8a and 9b-f demonstrated higher potencies than Vemurafenib against A375P. Compounds 8c and 9b were 7.50 and 454.90 times, respectively, more selective towards A375P melanoma cells over NIH3T3 fibroblasts. Furthermore, compounds 8d, e and 9a-d, f demonstrated very high potencies against the nine tested melanoma cell lines at the NCI. The bisamide derivatives 9a-c, f showed 2-digit nanomolar IC50 values over different cell lines of the NCI-9 melanoma cell lines.