123091-15-6

Basic information

• Product Name: Benzenesulfonic acid, 4-methyl-, 2-(dimethylamino)ethyl ester
• CAS NO: 123091-15-6
• Molecular Formula: C11H17NO3S
• Molecular Weight: 243.327
• Mol File: 123091-15-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzenesulfonic acid, 4-methyl-, 2-(dimethylamino)ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonic acid, 4-methyl-, 2-(dimethylamino)ethyl ester(123091-15-6)
• EPA Substance Registry System: Benzenesulfonic acid, 4-methyl-, 2-(dimethylamino)ethyl ester(123091-15-6)

Safety Data

• Hazardous Substances Data: 123091-15-6(Hazardous Substances Data)

Upstream product

• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 104-15-4 toluene-4-sulfonic acid 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 4385-05-1 4-(2-(N,N-dimethylamino)ethyl)morpholine 

Relevant articles and documents

Syntheses of chiral hybrid O,N-donor ligands for the investigation of lanthanide complex reactivities in direct aldol condensations

A method for the synthesis of new chiral α/β-dimethylamino esters and β-amino ethers from (S,S)-hydrobenzoin is described. These new O,N-donor ligands are expected to prove a useful platform for exploring the relationship between the ligand structure and

Synthesis and characterization of homopolymers bearing acid-cleavable cationic side-chains for ph-modulated release of DNA

A new type of homopolymers, PMAOE, bearing acid-cleavable cationic side-chains is synthesized and characterized. PMAOE is obtained via free radical polymerization, and they could efficiently bind and condense plasmid DNA at neutral pH. The strength of DNA binding is dependent on the length of PMAOE chains. NMR analysis reveals that hydrolysis of the ortho ester group of PMAOE follows an exocyclic mechanism and the rate of hydrolysis is much accelerated at mildly acidic pH, leading to accelerated disruption of polyplexes and release of DNA in mildly acidic environment. PMAOE is not toxic to cultured NIH 3T3 and COS-7 cells measured by MTT. This study demonstrates a unique mechanism of achieving pH-modulated binding and release of DNA from polymers with potential applications for gene delivery. A new mechanism of pH-modulated release of DNA from polymeric carrier (PMAOE) through a combination of cationic side-chain cleavage with increased polymer hydrophilicity and neutralization of residual cationic charges is demonstrated. These structurally simple side-chain degradable PMAOE homopolymers may have great potential as gene delivery vectors capable of releasing DNA in response to external or intracellular pH environment.

Method for synthesizing 4 - (2 - (N, N - dimethylamino) ethyl) morpholine (by machine translation)

The invention discloses a synthesis 4 - (2 - (N. The process. N- dimethylamino) ethyl) morpholine. Belong to fine chemical industry technical field. The technical scheme is: taking toluene as a solvent, N, N - dimethylethanolamine and p-toluenesulfonic acid under 110~120 °C heating reflux to carry out esterification reaction, and N, N - dimethylethanolamine p tosylate; N, N - dimethylethanolamine on tosylate reacts with morpholine, and the resulting reaction mixture is subjected to rectification to obtain a pure product. The method is cheap and easily available in raw materials, simple, mild, mild in reaction conditions, simple, high in yield, reusable, and capable of reducing cost. It is important that reaction process does not produce strong irritant gas, has reduced operating workman's health hazard greatly, does not need special corrosion-resistant equipment simultaneously, is favorable to the industrial production. (by machine translation)