1231220-79-3

Basic information

• Product Name: (8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine)
• Synonyms: (8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine)
• CAS NO: 1231220-79-3
• Molecular Weight: 426.949
• Mol File: 1231220-79-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 541.8±60.0 °C(Predicted)
• Density: 1.40±0.1 g/cm3(Predicted)
• CAS DataBase Reference: (8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine)(CAS DataBase Reference)
• NIST Chemistry Reference: (8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine)(1231220-79-3)
• EPA Substance Registry System: (8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine)(1231220-79-3)

Safety Data

• Hazardous Substances Data: 1231220-79-3(Hazardous Substances Data)

Usage

General Description

The chemical (8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine) is a complex compound with a molecular structure that includes a chlorophenyl group, a methyl group, a methylpiperazin-1-yl group, and a tetrahydro-2H-pyran-4-yl group attached to a purine ring. It is a purine derivative with potential therapeutic applications, potentially as a drug for the treatment of certain diseases or conditions, although specific uses and properties of this compound may vary. The complex structure and various functional groups present in this chemical make it a potential candidate for further research and development in the field of medicinal chemistry.

Upstream product

• 109-01-3 1-methyl-piperazine 
• 1231220-92-0 6-chloro-8-(2-chlorophenyl)-2-methyl-9-(tetrahydro-2H-pyran-4-yl)-9H-purine 
• 1418274-03-9 2-chloro-N-(4,6-dichloro-2-methylpyrimidin-5-yl)benzamide 
• 609-65-4 o-chlorobenzoyl chloride 
• 1231220-81-7 6-chloro-2-methyl-N₄-(tetrahydro-2H-pyran-4-yl)-pyrimidine-4,5-diamine 
• 38041-19-9 4-aminotetrahydropyran 
• 1418274-04-0 2-chloro-N-(4-chloro-2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-5-yl)benzamide 
• 39906-04-2 5-amino-4,6-dichloro-2-methylpyrimidine 
• 1231221-35-4 2-chloro-N-(4-chloro-2-methyl-6-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-5-yl)benzamide 

Downstream Products

• 1231219-45-6 8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-tetrahydropyran-4-yl-purine hydrochloride 

Relevant articles and documents

Selective cannabinoid receptor type 2 (CB2) agonists: Optimization of a series of purines leading to the identification of a clinical candidate for the treatment of osteoarthritic pain

A focused screening strategy identified thienopyrimidine 12 as a cannabinoid receptor type 2 agonist (hCB2) with moderate selectivity over the hCB1 receptor. This initial hit suffered from poor in vitro metabolic stability and high in vivo clearance. Structure-activity relationships describe the optimization and modification to a new more polar series of purine CB2 agonists. Examples from this novel scaffold were found to be highly potent and fully efficacious agonists of the human CB2 receptor with excellent selectivity against CB1, often having no CB1 agonist activity at the highest concentration measured (>100 μM). Compound 26 is a centrally penetrant molecule which possesses good biopharmaceutical properties, is highly water-soluble, and demonstrates robust oral activity in rodent models of joint pain. In addition, the peripherally restricted molecule 22 also demonstrated significant efficacy in the same analgesic model of rodent inflammatory pain.

Purine Compounds

A compound of the formula: and pharmaceutical compositions for the treatment of pain.