123185-86-4Relevant articles and documents
New chiral blocks for introducing the side chain of HMG-CoA reductase inhibitors
Urabe,Matsuka,Sato
, p. 4183 - 4186 (1992)
A couple of versatile building blocks (8 and 9) of the side chain portion found in many HMG-CoA reductase inhibitors have been prepared. The successful introduction of the side chain to an aromatic ring by 8 or 9 has been demonstrated.
Synthesis of an artificial HMG-CoA reductase inhibitor NK-104 via a hydrosilylation-cross-coupling reaction
Takahashi,Minami,Ohara,Hiyama
, p. 2649 - 2656 (2007/10/03)
The hydrosilylation of t-butyl (3R,5S)-3,5-isopropylidenedioxy-6-heptynoate with ClMe2SiH and a platinum catalyst, t-Bu3P·Pt(CH2 = CHSiMe2)2O, gave an (E)-vinylsilane in high yield with high regioselectivity. A subsequent cross-coupling reaction with an aryl halide afforded t-butyl (3R,5S,6E)-7-aryl-3,5-isopropylidene-dioxy-6-heptenoate. This sequence was applied to the synthesis of a potent HMC-CoA reductase inhibitor, NK-104.
A Potent, Tissue-Selective, Synthetic Inhibitor of HMG-CoA Reductase
Balasubramanian, N.,Brown, P. J.,Catt, J. D.,Han, W. T.,Parker, R. A.,et al.
, p. 2038 - 2041 (2007/10/02)
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