1232038-69-5

Basic information

• Product Name: 8-BroMo-3-iodo-iMidazo[1,2-a]pyridine
• Synonyms: 8-BroMo-3-iodo-iMidazo[1,2-a]pyridine
• CAS NO: 1232038-69-5
• Molecular Formula: C₇H₄BrIN₂
• Molecular Weight: 322.92853
• EINECS: -0
• Mol File: 1232038-69-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-BroMo-3-iodo-iMidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-BroMo-3-iodo-iMidazo[1,2-a]pyridine(1232038-69-5)
• EPA Substance Registry System: 8-BroMo-3-iodo-iMidazo[1,2-a]pyridine(1232038-69-5)

Safety Data

• Hazardous Substances Data: 1232038-69-5(Hazardous Substances Data)

Upstream product

• 13534-99-1 2-Amino-3-bromopyridine 
• 850349-02-9 8-bromoimidazo[1 ,2-a]pyridine 

Downstream Products

• 1232038-71-9 8-bromo-3-(4-fluorophenyl)imidazo[1,2-a]pyridine 
• 1232035-15-2 [3-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-[3-methoxy-4-(4-methyl-imidazol-1-yl)phenyl]amine 

Relevant articles and documents

From Synthetic Simplified Marine Metabolite Analogues to New Selective Allosteric Inhibitor of Aurora B Kinase

Significant inhibition of Aurora B was achieved by the synthesis of simplified fragments of benzosceptrins and oroidin belonging to the marine pyrrole-2-aminoimidazoles metabolites isolated from sponges. Evaluation of kinase inhibition enabled the discovery of a synthetically accessible rigid acetylenic structural analogue EL-228 (1), whose structure could be optimized into the potent CJ2-150 (37). Here we present the synthesis of new inhibitors of Aurora B kinase, which is an important target for cancer therapy through mitosis regulation. The biologically oriented synthesis yielded several nanomolar inhibitors. The optimized compound CJ2-150 (37) showed a non-ATP competitive allosteric mode of action in a mixed-type inhibition for Aurora B kinase. Molecular docking identified a probable binding mode in the allosteric site "F"and highlighted the key interactions with the protein. We describe the improvement of the inhibitory potency and specificity of the novel scaffold as well as the characterization of the mechanism of action.

MDM2 DEGRADERS AND USES THEREOF

The present invention relates to compounds and methods useful for the modulation of mouse double minute 2 homolog ("MDM2") protein via ubiquitination and/or degradation by compounds according to the present invention.

SUBSTITUTED BICYCLIC IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS

The present invention is concerned with novel substituted bicyclic imidazole derivatives of Formula (I) wherein R0, R1, R3, R4, X, A1, A2, A3, A4, Y1, Y2 and Y3 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said novel compound as an active ingredient as well as the use of said compounds as a medicament.