1232223-60-7

Basic information

• Product Name: (7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine
• Synonyms: (7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine
• CAS NO: 1232223-60-7
• Molecular Weight: 310.359
• Mol File: 1232223-60-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine(1232223-60-7)
• EPA Substance Registry System: (7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine(1232223-60-7)

Safety Data

• Hazardous Substances Data: 1232223-60-7(Hazardous Substances Data)

Upstream product

• 1159982-72-5 5,7-dichloro-2-phenylpyrazolo[1,5-a]pyrimidine 
• 1572-10-7 3⁽⁵⁾-phenylpyrazol-5⁽³⁾-amine 

Downstream Products

• 1232221-52-1 N-(1H-indol-4-yl-methylidene)-N'-(7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine 
• 1232221-48-5 N-(2-methyl-benzofuran-7-yl-methylidene)-N'-(7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine 
• 1232221-56-5 N-(2-methoxy-benzothiazol-4-yl-methylidene)-N'-(7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine 
• 1232222-88-6 N-(3-amino-benzylidene)-N'-(7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine 
• 1232222-86-4 N-(3-boronyl-benzylidene)-N'-(7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine 
• 1232221-42-9 N-(2-methyl-1H-indol-7-yl-methylidene)-N'-(7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine 
• 1232221-58-7 N-(6-methyl-imidazo[2,1-b]thiazole-5-methylidene)-N'-(7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine 
• 1232221-60-1 N-(6-chloro-imidazo[2,1-b]thiazole-5-methylidene)-N'-(7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine 
• 1232221-64-5 N-(2-methyl-1H-indol-3-yl-methylidene)-N'-(7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine 
• 1232220-13-1 N-(1H-indol-3-yl-methylidene)-N'-(7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine 
• 1232221-62-3 N-(3-methyl-1H-indol-7-yl-methylidene)-N'-(7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine 
• 1232221-54-3 N-(1H-indol-7-yl-methylidene)-N'-(7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine 
• 1232221-50-9 N-(2,2-dimethyl-2,3-dihydro-benzofuran-7-yl-methyl-idene)-N'-(7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)hydrazine 
• 1232220-23-3 N-benzylidene-N'-(7-morpholin-4-yl-2-phenyl-pyrazolo-[1,5-a]pyrimidin-5-yl)-hydrazine 

Relevant articles and documents

Structure-activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201

Interleukin-12 (IL-12) and IL-23 are proinflammatory cytokines and therapeutic targets for inflammatory and autoimmune diseases, including inflammatory bowel diseases, psoriasis, rheumatoid arthritis, and multiple sclerosis. We describe the discovery of APY0201, a unique small molecular IL-12/23 production inhibitor, from activated macrophages and monocytes, and demonstrate ameliorated inflammation in an experimental model of colitis. Through a chemical proteomics approach using a highly sensitive direct nanoflow LC-MS/MS system and bait compounds equipped with the FLAG epitope associated regulator of PIKfyve (ArPIKfyve) was detected. Further study identified its associated protein phosphoinositide kinase, FYVE finger-containing (PIKfyve), as the target protein of APY0201, which was characterized as a potent, highly selective, ATP-competitive PIKfyve inhibitor that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2. These results elucidate the function of PIKfyve kinase in the IL-12/23 production pathway and in IL-12/23-driven inflammatory disease pathologies to provide a compelling rationale for targeting PIKfyve kinase in inflammatory and autoimmune diseases.