123261-65-4

Basic information

• Product Name: Butanoic acid, 3-oxo-, (1R)-1-phenylethyl ester
• CAS NO: 123261-65-4
• Molecular Formula: C12H14O3
• Molecular Weight: 206.241
• Mol File: 123261-65-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 3-oxo-, (1R)-1-phenylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 3-oxo-, (1R)-1-phenylethyl ester(123261-65-4)
• EPA Substance Registry System: Butanoic acid, 3-oxo-, (1R)-1-phenylethyl ester(123261-65-4)

Safety Data

• Hazardous Substances Data: 123261-65-4(Hazardous Substances Data)

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 1517-69-7 (R)-1-phenylethanol 
• 98-85-1 1-Phenylethanol 
• 105-45-3 acetoacetic acid methyl ester 
• 40552-84-9 1-phenylethyl acetoacetate 

Downstream Products

• 1226918-02-0 (R)-1-phenylethyl 6-chloro-2-methyl-4-phenylquinoline-3-carboxylate 

Relevant articles and documents

A highly chemo- and stereoselective synthesis of β-keto esters via a polymer-supported lipase catalyzed transesterfication

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Highly selective resolution of secondary alcohols and acetoacetates with lipases and diketene in organic media

By the catalysis of lipases, racemic 1-phenylethanol 1a is reacted with diketene in isopropyl ether at room temperature to give (S)-1a (R1 = Me, R2 = Ph, 36%, 99% ee) and (R)-1-phenylethyl acetoacetate 2a (51%, 77% ee). The strategy was also successfully applied to racemic 1-(1-naphthyl)ethanol 1b, 1-(2-naphthyl)ethanol 1c, 1-phenyl-2-propanol 1d, 1,2,3,4-tetrahydro-1-naphthol 1e, and 2-octanol 1f with high E-values up to > 100.