1232829-94-5Relevant articles and documents
Discovery and optimisation of 1-acyl-2-benzylpyrrolidines as potent dual orexin receptor antagonists
Williams, Jodi T.,Gatfield, John,Roch, Catherine,Treiber, Alexander,Jenck, Francois,Bolli, Martin H.,Brotschi, Christine,Sifferlen, Thierry,Heidmann, Bibia,Boss, Christoph
, p. 1054 - 1064 (2015)
Starting from a thienopiperidine lead compound with high intrinsic clearance in rat and human liver microsomes and low aqueous solubility, a novel series of 1-acyl-2-benzylpyrrolidines were discovered as potent and competitive dual orexin receptor antagon