1233210-78-0

Basic information

• Product Name: C₂₂H₂₂N₂O₂
• Synonyms: C₂₂H₂₂N₂O₂
• CAS NO: 1233210-78-0
• Molecular Weight: 346.429
• Mol File: 1233210-78-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₂N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₂N₂O₂(1233210-78-0)
• EPA Substance Registry System: C₂₂H₂₂N₂O₂(1233210-78-0)

Safety Data

• Hazardous Substances Data: 1233210-78-0(Hazardous Substances Data)

Upstream product

• 56030-23-0 3-(3-formylphenyl)acrylic acid 
• 74628-31-2 N-1-cyclohexylbenzene-1,2-diamine 

Relevant articles and documents

Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity

A series of N-hydroxy-3-[3-(1-substituted-1H-benzoimidazol-2-yl)-phenyl]-acrylamides (5a-5ab) and N-hydroxy-3-[3-(1,4,5-trisubstituted-1H-imidazol-2-yl)-phenyl]-acrylamides (12a-s) were designed, synthesized, and found to be nanomolar inhibitors of human histone deacetylases. Multiple compounds bearing an N1-piperidine demonstrate EC50s of 20-100 nM in human A549, HL60, and PC3 cells, in vitro and in vivo hyperacetylation of histones H3 and H4, and induction of p21waf. Compound 5x displays efficacy in human tumor xenograft models.