1233246-23-5

Basic information

• Product Name: C₂₂H₁₈Cl₂N₄O₃
• CAS NO: 1233246-23-5
• Molecular Weight: 457.316
• Mol File: 1233246-23-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₈Cl₂N₄O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₈Cl₂N₄O₃(1233246-23-5)
• EPA Substance Registry System: C₂₂H₁₈Cl₂N₄O₃(1233246-23-5)

Safety Data

• Hazardous Substances Data: 1233246-23-5(Hazardous Substances Data)

Upstream product

• 509083-73-2 4-((5S,9R)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro-[4.4]nonan-9-yl)benzonitrile 
• 13054-02-9 6-iodo-nicotinic acid 
• 127-19-5 N,N-dimethyl acetamide 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 

Relevant articles and documents

A new and efficient synthesis of 6-[(5 S,9 R)-9-(4-Cyanophenyl)-3-(3,5- dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl]nicotinic acid, a potent LFA-1/ICAM inhibitor

An efficient synthesis of 6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5- dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl]nicotinic acid 1 is described. This new process involves an in situ protection of 6-chloronicotinic acid as trimethylsilyl est