1233488-54-4

Basic information

• Product Name: 2-(2-isopropoxyphenyl)-5-nitro-1H-benzo[d]imidazole
• Synonyms: 2-(2-isopropoxyphenyl)-5-nitro-1H-benzo[d]imidazole
• CAS NO: 1233488-54-4
• Molecular Weight: 297.313
• Mol File: 1233488-54-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-isopropoxyphenyl)-5-nitro-1H-benzo[d]imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-isopropoxyphenyl)-5-nitro-1H-benzo[d]imidazole(1233488-54-4)
• EPA Substance Registry System: 2-(2-isopropoxyphenyl)-5-nitro-1H-benzo[d]imidazole(1233488-54-4)

Safety Data

• Hazardous Substances Data: 1233488-54-4(Hazardous Substances Data)

Upstream product

• 22921-58-0 2-isopropoxybenzaldehyde 
• 99-56-9 4-Nitrophenylene-1,2-diamine 

Relevant articles and documents

Synthesis, vasorelaxant activity and antihypertensive effect of benzo[d]imidazole derivatives

A series of 1H-benzo[d]imidazole analogues of Pimobendan, substituted at position 5 with either -CF3 or -NO2, were synthesized using a short synthetic route. All the nitro derivatives were potent, and exhibited a concentration- and partial endothelium-dependent vasorelaxant effects, with EC50s 50 value of 1.81 μM and Emax of 91.7% for ex vivo relaxant response in intact aortic rings, resulting in a 2.5-fold higher activity compared to Pimobendan. The closely related 5-CF3 analogue (compound 8), was 19 times less potent than 13. The antihypertensive activity of compound 13 was evaluated at doses of 25, 50 and 100 mg kg-1, using spontaneously hypertensive rats (SHR), showing a statistically significant dose-dependent effect.