1233510-37-6Relevant articles and documents
Asymmetric vinylogous aldol reaction of silyloxy furans with a chiral organic salt
Singh, Ravi P.,Foxman, Bruce M.,Deng, Li
supporting information; experimental part, p. 9558 - 9560 (2010/08/20)
Despite their synthetic significance there is a general lack of asymmetric vinylogous aldol reactions that tolerate variations of both the silyloxy furans and aldehydes. We have developed a new chiral organic catalyst based on a carboxylate-ammonium salt prepared from a thiourea-amine and a carboxylic acid. This new catalyst enabled us to develop an efficient asymmetric vinylogous aldol reaction of unprecedented scope with respect to both 2-trimethylsilyloxy furans and aldehydes.
