123417-18-5 Usage
Description
BOC-GLU(OFM)-OH, also known as Boc-Glu(O-tert-butyl)-OH, is a chemical compound used in the synthesis of peptides and proteins. It is a white to off-white powder with specific chemical properties that make it suitable for various applications in the pharmaceutical and biotechnology industries.
Uses
Used in Pharmaceutical Industry:
BOC-GLU(OFM)-OH is used as a building block in the synthesis of peptides and proteins for various therapeutic applications. Its chemical properties allow for the formation of stable peptide bonds, which are essential for the structure and function of biologically active molecules.
Used in Biotechnology Industry:
BOC-GLU(OFM)-OH is used as a reagent in solid-phase peptide synthesis, a technique used to produce peptides and proteins in a stepwise manner. This method allows for the efficient and controlled synthesis of complex peptide sequences, which can be used for research, drug development, and other applications.
Used in Insulin Synthesis:
BOC-GLU(OFM)-OH is used in the synthesis of [AspB10,LysB28,ProB29]-ester insulin, a modified form of insulin with improved pharmacokinetic properties. This modified insulin has potential applications in the treatment of diabetes, as it may offer advantages over traditional insulin formulations in terms of efficacy and convenience.
Check Digit Verification of cas no
The CAS Registry Mumber 123417-18-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,4,1 and 7 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 123417-18:
(8*1)+(7*2)+(6*3)+(5*4)+(4*1)+(3*7)+(2*1)+(1*8)=95
95 % 10 = 5
So 123417-18-5 is a valid CAS Registry Number.
InChI:InChI=1/C24H27NO6/c1-24(2,3)31-23(29)25-20(22(27)28)12-13-21(26)30-14-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,25,29)(H,27,28)/t20-/m0/s1
123417-18-5Relevant articles and documents
Solid-phase synthesis of peptidyl thioacids employing a 9-fluorenylmethyl thioester-based linker in conjunction with Boc chemistry
Crich, David,Sana, Kasinath
scheme or table, p. 7383 - 7388 (2010/01/16)
(Chemical Equation Presented) A method for the synthesis of peptidyl thioacids is described on the basis of the use of the N-[9-(thiomethyl)-9H- fluoren-2-yl]succinamic acid and cross-linked aminomethyl polystyrene resin. The method employs standard Boc chemistry SPPS techniques in conjunction with 9-fluorenylmethyloxycarbonyl protection of side-chain alcohols and amines and 9-fluorenylmethyl protection of side-chain acids and thiols. Cleavage from the resin is accomplished with piperidine, which also serves to remove the side-chain protection and avoids the HF conditions usually associated with the resin cleavage stage of Boc chemistry SPPS. The so-obtained thioacids are converted to simple thioesters in high yield by standard alkylation according to well-established methods. 2009 American Chemical Society.
Convenient Syntheses of Fluorenylmethyl-Based Side Chain Derivatives of Glutamic and Aspartic acids, Lysine and Cysteine
Albericio, F.,Nicolas, E.,Rizo, J.,Ruiz-Gayo, M.,Pedroso, E.,Giralt, E.
, p. 119 - 122 (2007/10/02)
Efficient and practical one-pot syntheses of the fluorenylmethyl-based side chain derivatives of glutamic and aspartic acids, lysine, and cysteine are described.Likewise, stability/lability of these derivatives towards solvents and reagents used in solid