1234319-92-6Relevant articles and documents
15N double-labeled guanosine from inosine through ring-opening-ring-closing and one-pot Pd-catalyzed C-O and C-N cross-coupling reactions
Caner, Joaquim,Vilarrasa, Jaume
supporting information; experimental part, p. 4880 - 4883 (2010/10/19)
(Figure Presented) [N,1-15N2]-Guanosine, or [1,NH2-15N2]-guanosine, and derivatives were prepared from tri-O-acetylinosine, via N-nitration and reaction with 15NH2OH, followed by conversion of the 15N-labeled 1-hydroxyinosine to the corresponding 2,6-dichloropurine riboside. The sequential one-pot C-O and C-N key couplings of this dichloro derivative with PhCH2OH and PhCO15NH2 or iPrCO15NH2 was achieved in good overall yields, with Pd(0)-Xantphos as the best choice of five different catalytic systems examined.