1234321-77-7 Usage
Description
(Z)-3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)-2-butenoic acid methyl ester, commonly referred to as (Z)-TBOA, is a chemical compound utilized as a research tool in the field of neuroscience. It is characterized by its selective blocking action on excitatory amino acid transporters and functions as a competitive antagonist at the glutamate binding site. This property makes (Z)-TBOA a valuable asset in the study of glutamate signaling, synaptic transmission, and the role of excitatory amino acid transporters in various neurological disorders.
Uses
Used in Neuroscience Research:
(Z)-TBOA is used as a research tool for studying the regulation of glutamate signaling and synaptic transmission. Its ability to act as a competitive antagonist at the glutamate binding site allows researchers to investigate the role of excitatory amino acid transporters in neurological disorders.
Used in Pharmaceutical Development:
(Z)-TBOA is used as a reference compound in the development and evaluation of new drugs targeting glutamate transporters. Its inhibitory effects on these transporters make it a valuable asset in the search for potential therapeutic applications for conditions such as epilepsy, stroke, and neurodegenerative diseases.
Used in the Treatment of Neurological Disorders:
(Z)-TBOA is used as a potential therapeutic agent for treating conditions like epilepsy, stroke, and neurodegenerative diseases. Its inhibitory effects on glutamate transporters can help in understanding the underlying mechanisms of these disorders and pave the way for the development of novel treatment strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 1234321-77-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,4,3,2 and 1 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1234321-77:
(9*1)+(8*2)+(7*3)+(6*4)+(5*3)+(4*2)+(3*1)+(2*7)+(1*7)=117
117 % 10 = 7
So 1234321-77-7 is a valid CAS Registry Number.
1234321-77-7Relevant articles and documents
Nickel-Catalyzed Asymmetric Hydrogenation for the Synthesis of a Key Intermediate of Sitagliptin
Sudhakaran, Shana,Shinde, Prasad G.,Aratikatla, Eswar K.,Kaulage, Sandeep H.,Rana, Priksha,Parit, Ratan S.,Kavale, Dattatry S.,Senthilkumar, Beeran,Punji, Benudhar
supporting information, (2021/12/09)
Nickel-catalyzed enantioselective hydrogenation of enamines leading to the efficient synthesis of 3-R-Boc-amino-4-(2,4,5-trifluorophenyl)butyric esters, the key intermediate of the blockbuster antidiabetic drug (R)-SITAGLIPTIN, is described. The sitagliptin motifs were isolated in more than 99% yield and with 75–92% ee using the earth-abundant nickel catalyst. Upon chiral resolution with (R)- and (S)-1-phenylethylamines, the partially enantioenriched (R)- and (S)-Boc-3-amino-4-(2,4,5-trifluorophenyl)butanoic acids provided >99.5% ee of the crucial sitagliptin intermediate. The asymmetric hydrogenation protocol was scaled up to 10 g with consistency in yield and ee, and has been reproduced in multiple batches.
