1234321-81-3

Basic information

• Product Name: Methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate
• Synonyms: Methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate;(Z)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate;(2Z)-3-(Acetylamino)-4-(2,4,5-trifluorophenyl)-2-butenoic acid methyl ester
• CAS NO: 1234321-81-3
• Molecular Formula: C₁₃H₁₂F₃NO₃
• Molecular Weight: 287.2344896
• EINECS: -0
• Mol File: 1234321-81-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 436.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.304±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 13.58±0.46(Predicted)
• CAS DataBase Reference: Methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate(1234321-81-3)
• EPA Substance Registry System: Methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate(1234321-81-3)

Safety Data

• Hazardous Substances Data: 1234321-81-3(Hazardous Substances Data)

Usage

General Description

Methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate is a chemical compound with the molecular formula C14H14F3NO3. It is a synthetic organic compound that is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is a pale yellow solid at room temperature and is insoluble in water but soluble in organic solvents. Methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate is used in the production of various drugs and has potential applications in the field of medicinal chemistry and drug discovery. Additionally, it is commonly used as a reagent in chemical research and synthesis.

Upstream product

• 209995-38-0 (2,4,5-trifluorophenyl)acetic acid 
• 764667-64-3 5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 67-56-1 methanol 
• 631-61-8 ammonium acetate 
• 769195-26-8 4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester 
• 60-35-5 acetamide 
• 881995-70-6 (2Z)-3-amino-4-(2,4,5-trifluorophenyl)but-2-enoic acid methyl ester 
• 108-24-7 acetic anhydride 

Downstream Products

• 1234321-83-5 (R)-methyl-3-N-acetylamino-4-(2,4,5-trifluorophenyl)butanoate 
• 486460-00-8 (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid 
• 486460-23-5 (R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate 
• 486460-32-6 sitagliptin 

Relevant articles and documents

Preparation method of chiral 4 - aryl - β β-amino acid derivative

Provided is a method for preparing a chiral 4-aryl-β-amino acid derivative. The preparation method comprises hydrogenating an enamine compound having a structure as shown in Formula III in an organic solvent in the presence of a catalyst containing a transition metal and BIBOPs. The preparation method of the present invention uses a small amount of a selected asymmetric catalyst, and has a simple operation, mild reaction conditions, a high yield, a high stereoselectivity, and better industrial application and economic values.

Highly efficient and facile synthesis of β-enaminones catalyzed by diphenylammonium triflate

Abstract: The catalytic performance of diphenylammonium triflates as an organocatalyst in the synthesis of β-enaminones from various substituted β-diketones and amides (or amines) were evaluated. A wide range of β-enaminones were efficiently synthesized in good to excellent yields under mild reaction conditions. Applying diphenylammonium triflate (DPAT) as catalyst makes this protocol cost-effective, low corrosive and easy to handle. Graphic abstract: [Figure not available: see fulltext.].