123439-12-3

Basic information

• Product Name: 4-amino[2.2]paracyclophane
• Synonyms: 4-amino[2.2]paracyclophane
• CAS NO: 123439-12-3
• Molecular Weight: 223.318
• Mol File: 123439-12-3.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 4-amino[2.2]paracyclophane(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino[2.2]paracyclophane(123439-12-3)
• EPA Substance Registry System: 4-amino[2.2]paracyclophane(123439-12-3)

Safety Data

• Hazardous Substances Data: 123439-12-3(Hazardous Substances Data)

Upstream product

• 380626-41-5 N-tert-butyl-[2.2]paracyclophane-4-ylcarbamate 
• 20586-49-6 [2.2]paracyclophane-4-carboxylic acid 
• 196316-30-0 4,16-dibromo[2.2]paracyclophane 
• 36325-27-6 4-formyl[2.2]paracyclophane 
• 1227781-48-7 (rac)-4-azido[2.2]paracyclophane 
• 202345-41-3 (4R(p),13S(p))-4-amino-13-bromo[2.2]paracyclophane 
• 1633-22-3 [2.2]Paracyclophan 
• 1908-61-8 4-bromo[2.2]paracyclophane 
• 123535-94-4 12-nitro-1,4(1,4)-dibenzenacyclohexaphane 

Downstream Products

• 14778-29-1 1,1,2,2,-tetracyanoethane 
• 1228016-63-4 C₃₁H₃₉N₂P 
• 1227781-55-6 C₃₁H₃₉N₂OP 
• 1227781-56-7 C₃₁H₃₉N₂PSe 
• 10122-95-9 (R_p)-1,4(1,4)-dibenzenacyclohexaphan-1²-amine 
• 196086-92-7 (±)-4-benzylamino[2.2]paracyclophane 
• 1228551-88-9 rac-N-(4-[2.2]paracyclophanylen)-N'-(3,5-bis-(trifluoromethyl)phenyl)thiourea 

Relevant articles and documents

N-(4-[2.2]paracyclophanyl)-2′-hydroxyacetophenone imine: An effective paracyclophane Schiff-base ligand for use in catalytic asymmetric cyclopropanation reactions

The synthesis of planar chiral N-(4-[2.2]paracyclophanyl)-2′- hydroxyacetophenone imine (5) and its use as a ligand for the copper(II) catalyzed cyclopropanation of styrene and stilbene derivatives using diazoesters is presented. Catalyst loadings of 0.1

Para-Functionalization of N-Substituted 4-amino[2.2]paracyclophanes by Regioselective Formylation

Herein, we report a simple and convenient procedure to prepare para-disubstituted [2.2]paracyclophanes in a straightforward manner. Our approach relies on a regioselective formylation of N-substituted 4-amino[2.2]paracyclophanes, which allows an easy access to a series of products incorporating a reactive aldehyde function para to the electron-donating group. These compounds can be engaged in a variety of orthogonal late-stage derivatization processes involving either the carbonyl group or the amine function, and can serve as precursors to rapidly access more complex paracyclophane derivatives. Control of planar chirality is also possible by performing a kinetic resolution of key racemic intermediates through asymmetric transfer hydrogenation. The formylation can be run on a synthetically useful scale, thus confirming the practical applicability of our method.

A Parylene A precursor synthesis method (by machine translation)

The invention discloses a Parylene A precursor synthesis method, comprises the following steps: (1) to [2, 2] - to di-methyl benzene ring b body as raw materials through the nitration reaction to obtain the intermediate product 4 - nitro - [2, 2] - dimethyl benzene ring to the second body; (2) the intermediate product 4 - nitro - [2, 2] - dimethyl benzene ring on the second body is arranged in the reactor into the hydrogen in the hydrogenation catalyst under the action of the reduction reaction, to get the crude product, concentrated, recrystallization, dried to obtain 4 - amino - [2, 2] - dimethyl benzene ring on the second body. The mild reaction conditions of the method, the resulting product yield and purity are relatively high, the catalyst and the solvent can be recycled, is suitable for mass production. (by machine translation)