1234569-92-6Relevant articles and documents
Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli
Lamoral-Theys, Delphine,Pottier, Laurent,Kerff, Frédéric,Dufrasne, Fran?ois,Proutière, Fabien,Wauthoz, Nathalie,Neven, Philippe,Ingrassia, Laurent,Antwerpen, Pierre Van,Lefranc, Florence,Gelbcke, Michel,Pirotte, Bernard,Kraus, Jean-Louis,Nève, Jean,Kornienko, Alexander,Kiss, Robert,Dubois, Jacques
experimental part, p. 3823 - 3833 (2010/08/19)
A series of 33 novel divanillates and trivanillates were synthesized and found to possess promising cytostatic rather than cytotoxic properties. Several compounds under study decreased by >50% the activity of Aurora A, B, and C, and WEE1 kinase activity at concentrations 50 growth inhibitory ones, accounting, at least partly, for their cytostatic effects in cancer cells and to a lesser extent in normal cells. Compounds 6b and 13c represent interesting starting points for the development of cytostatic agents to combat cancers, which are naturally resistant to pro-apoptotic stimuli, including metastatic malignancies.
