123458-61-7 Usage
Description
Δ2-Cefuroxime Axetil is an oral prodrug of Cefuroxime (C248060), which is an injectable second-generation cephalosporin antibiotic known for its excellent antibacterial activity. This ester is utilized in therapy as a mixture of the R and S diastereoisomers.
Uses
Used in Pharmaceutical Industry:
Δ2-Cefuroxime Axetil is used as an oral prodrug for the treatment of various bacterial infections. It is particularly effective due to its excellent antibacterial activity, making it a valuable addition to the arsenal of antibiotics used to combat resistant bacteria.
As an oral prodrug, Δ2-Cefuroxime Axetil offers the advantage of being more easily administered compared to its injectable counterpart, Cefuroxime. This allows for greater patient compliance and convenience, making it a preferred choice for certain types of bacterial infections.
Check Digit Verification of cas no
The CAS Registry Mumber 123458-61-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,4,5 and 8 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 123458-61:
(8*1)+(7*2)+(6*3)+(5*4)+(4*5)+(3*8)+(2*6)+(1*1)=117
117 % 10 = 7
So 123458-61-7 is a valid CAS Registry Number.
123458-61-7Relevant articles and documents
Cefuroxime axetil-3-ene isomer preparation method
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Paragraph 0019-0034, (2020/01/03)
The invention relates to a cefuroxime axetil-3-ene isomer preparation method, and belongs to medicine quality research, quality control and safety research of pharmaceutical enterprises. The steps comprise: (1) in an aprotic solvent and a protic solution, generating a 3-ene isomeric cefuroxime axetil and cefuroxime axetil mixture from cefuroxime axetil under the catalytic action of an alkali; and(2) purifying the 3-ene isomeric cefuroxime axetil and cefuroxime axetil mixture obtained in the step (1) through reversed-phase C18 column preparative liquid chromatography, extracting, drying, andconcentrating to obtain the cefuroxime axetil-3-ene isomer, wherein the chromatographic conditions of purifying comprise that a ratio of water to methanol is 40/60, the flow rate is 40 ml/min, and theultraviolet detection wavelength is 23 nm. According to the invention, the method has advantages of simple reaction operation, mild conditions and high product purity, and the obtained cefuroxime axetil-3-ene isomer can be used as a standard substance in quality control of cefuroxime axetil bulk drugs and preparations.