123506-49-0

Basic information

• Product Name: 7-Amino-3-methyl-2,4-dioxo-5-phenyl-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester
• Synonyms: 7-Amino-3-methyl-2,4-dioxo-5-phenyl-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester
• CAS NO: 123506-49-0
• Molecular Weight: 340.338
• Mol File: 123506-49-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7-Amino-3-methyl-2,4-dioxo-5-phenyl-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Amino-3-methyl-2,4-dioxo-5-phenyl-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester(123506-49-0)
• EPA Substance Registry System: 7-Amino-3-methyl-2,4-dioxo-5-phenyl-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester(123506-49-0)

Safety Data

• Hazardous Substances Data: 123506-49-0(Hazardous Substances Data)

Upstream product

• 21236-97-5 3-methyl-6-aminouracil 
• 14533-87-0 (Z)-ethyl 2-cyano-3-phenylacrylate 
• 100-52-7 benzaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 
• 123506-39-8 6-hydroxyamino-3-methyluracil 
• 2025-40-3 ethyl benzylidenecyanoacetate 

Relevant articles and documents

New strategy for the oxidation of Hantzsch 1,4-dihydropyridines and dihydropyrido[2,3-d]pyrimidines catalyzed by DMSO under aerobic conditions

A novel metal-salt-oxidant-free, efficient, and economical method for the oxidation of Hantzsch 1,4-dihydropyridines that uses aerial oxygen and solvent-grade dimethylsulfoxide is described. Also, the synthesis of pyrido[2,3-d]pyrimidines is achieved from in situ oxidation of dihydropyrido[2,3-d]pyrimidines that arise from the reaction of 6-aminouracils and cyano olefins in dimethylsulfoxide. Copyright Taylor & Francis Group, LLC.

Studies on Uracils. 10. A Facile One-Pot Synthesis of Pyrido- and Pyrazolopyrimidines

The reaction of functionalised uracils bearing amino and hydroxyamino groups at C-6 position (4 and 5) with strongly electrophilic cyano olefins (1,2 and 3) gave rise to pyridopyrimidines 7-9 in excellent yields.Hydrazine-substituted uracil 6 gave access to an efficient one-step synthesis of pyrazolopyrimidines 10.The capture of an eliminated hydrogen molecule by cyano olefins in the case of their reaction with 4 and 6 was confirmed by the isolation of dihydrocyano olefins.This fact further supported the plausible mechanism for the formation of compounds 7-10 via dihydropyrido- and dihydropyrazolopyrimidine intermediates A and C.