123530-66-5 Usage
Description
(E)-3-(pyrazin-2-yl)acrylic acid, a pyrazine derivative with the chemical formula C7H6N2O2, belongs to the class of organic compounds known as pyrazines. This chemical compound is recognized for its potential biological activities and interactions with various biological targets, making it a valuable component in drug discovery and medicinal chemistry research.
Uses
Used in Pharmaceutical and Agrochemical Industries:
(E)-3-(pyrazin-2-yl)acrylic acid is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, contributing to the development of new drugs and agricultural products.
Used in Dye and Pigment Production:
(E)-3-(pyrazin-2-yl)acrylic acid is also utilized in the production of dyes, pigments, and other fine chemicals, highlighting its versatility in different industrial applications.
Used in Drug Discovery and Medicinal Chemistry Research:
Due to its potential biological activities and interactions with various biological targets, (E)-3-(pyrazin-2-yl)acrylic acid plays a significant role in drug discovery and medicinal chemistry research, aiding in the advancement of novel therapeutic agents.
It is crucial to handle (E)-3-(pyrazin-2-yl)acrylic acid with care, as it may pose health and environmental hazards if not properly managed.
Check Digit Verification of cas no
The CAS Registry Mumber 123530-66-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,5,3 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 123530-66:
(8*1)+(7*2)+(6*3)+(5*5)+(4*3)+(3*0)+(2*6)+(1*6)=95
95 % 10 = 5
So 123530-66-5 is a valid CAS Registry Number.
123530-66-5Relevant articles and documents
Synthesis and evaluation of N-heteroaromatic ring-based analogs of piperlongumine as potent anticancer agents
Zou, Yu,Yan, Chang,Zhang, Huibin,Xu, Jinyi,Zhang, Dayong,Huang, Zhangjian,Zhang, Yihua
, p. 313 - 319 (2017/07/07)
Piperlongumine (PL) selectively targets a wide spectrum of cancer cells and induces their death by triggering various pathways, including apoptosis, necrosis and autophagy. However, the poor solubility is a serious concern for intensive study and clinical application. We synthesized its analogs 1–9 by replacement of the trimethoxyphenyl of PL with an N-heteroaromatic ring and/or not introduction of 2-Cl. These compounds improved aqueous solubility and displayed potent anticancer activity. The most active compound 9 selectively enhanced ROS levels in colon cancer cells and inhibited the cell proliferation but sparing non-tumor colon cells. Importantly, 9 significantly repressed tumor growth in an HCT-116 xenograft mouse model, suggesting that these N-heteroaromatic ring-based analogs of PL warrant further investigation.
