123531-27-1

Basic information

• Product Name: ethyl iMidazo[1,2-b]pyridazine-2-carboxylate
• Synonyms: ethyl iMidazo[1,2-b]pyridazine-2-carboxylate;Imidazo[1,2-b]pyridazine-2-carboxylic acid ethyl ester
• CAS NO: 123531-27-1
• Molecular Formula: C₉H₉N₃O₂
• Molecular Weight: 191.18666
• Mol File: 123531-27-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ethyl iMidazo[1,2-b]pyridazine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl iMidazo[1,2-b]pyridazine-2-carboxylate(123531-27-1)
• EPA Substance Registry System: ethyl iMidazo[1,2-b]pyridazine-2-carboxylate(123531-27-1)

Safety Data

• Hazardous Substances Data: 123531-27-1(Hazardous Substances Data)

Usage

Description

Ethyl imidazo[1,2-b]pyridazine-2-carboxylate is a chemical compound with the molecular formula C11H11N3O2. It is a pyridazine derivative with an imidazole ring and an ethyl ester group. This versatile compound has been studied for its potential pharmaceutical properties, including its antiviral and antifungal activities, as well as its potential use as a building block in organic synthesis.

Uses

Used in Pharmaceutical Industry:
Ethyl imidazo[1,2-b]pyridazine-2-carboxylate is used as a pharmaceutical agent for its antiviral and antifungal activities. Its unique structure allows it to target specific pathogens and inhibit their growth, making it a promising candidate for the development of new drugs to combat viral and fungal infections.
Used in Organic Synthesis:
Ethyl imidazo[1,2-b]pyridazine-2-carboxylate is used as a building block in organic synthesis. Its imidazole and pyridazine rings provide a versatile platform for the creation of new compounds with various applications, including pharmaceuticals, agrochemicals, and materials science. Its ethyl ester group can be easily modified, allowing for the synthesis of a wide range of derivatives with tailored properties.

Upstream product

• 64067-99-8 ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate 
• 70-23-5 ethyl Bromopyruvate 
• 5469-70-5 3-aminopyridazine 

Downstream Products

• 160911-42-2 imidazo[1,2-b]pyridazine-2-carboxylic acid 
• 123531-29-3 Imidazo[1,2-b]pyridazine-2-carboxylic acid amide 

Relevant articles and documents

The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging

As part of our effort in identifying phosphodiesterase (PDE) 4B-preferring inhibitors for the treatment of central nervous system (CNS) disorders, we sought to identify a positron emission tomography (PET) ligand to enable target occupancy measurement in vivo. Through a systematic and cost-effective PET discovery process, involving expression level (Bmax) and biodistribution determination, a PET-specific structure-activity relationship (SAR) effort, and specific binding assessment using a LC-MS/MS "cold tracer" method, we have identified 8 (PF-06445974) as a promising PET lead. Compound 8 has exquisite potency at PDE4B, good selectivity over PDE4D, excellent brain permeability, and a high level of specific binding in the "cold tracer" study. In subsequent non-human primate (NHP) PET imaging studies, [18F]8 showed rapid brain uptake and high target specificity, indicating that [18F]8 is a promising PDE4B-preferring radioligand for clinical PET imaging.

IMIDAZOPYRIDAZINE COMPOUNDS

The present invention is directed to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the substituents R1, R3, R6, R7, and b are as defined herein. The invention is also directed to pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, and methods of preparing the compounds.