1235444-12-8

Basic information

• Product Name: N'-(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-ylcarbonyloxy)-(3,4-dimethoxyphenyl)acetimidamide
• CAS NO: 1235444-12-8
• Molecular Weight: 442.512
• Mol File: 1235444-12-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N'-(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-ylcarbonyloxy)-(3,4-dimethoxyphenyl)acetimidamide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-ylcarbonyloxy)-(3,4-dimethoxyphenyl)acetimidamide(1235444-12-8)
• EPA Substance Registry System: N'-(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-ylcarbonyloxy)-(3,4-dimethoxyphenyl)acetimidamide(1235444-12-8)

Safety Data

• Hazardous Substances Data: 1235444-12-8(Hazardous Substances Data)

Upstream product

• 784143-45-9 N-hydroxysuccinimidyl trolox ester 
• 42191-48-0 2-(3,4-dimethoxy-phenyl)-acetamide oxime 

Downstream Products

• 1235444-14-0 5-(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)-3-(3,4-dimethoxybenzyl)-1,2,4-oxadiazole 

Relevant articles and documents

Synthesis of a second generation chroman/catechol hybrids and evaluation of their activity in protecting neuronal cells from oxidative stress-induced cell death

A new generation of chroman/catechol hybrids bearing heterocyclic five-membered rings, such as 1,2,4-oxadiazole 1,3,4-oxadiazole, 1,2,3-triazole, tetrazole and isoxazole, were designed and synthesized. The activity of the new derivatives against oxidative stress induced neuronal damage, was evaluated using glutamate-challenged hippocampal HT22 cells. Compound 3 in which a 3,4-dimethoxyphenyl moiety, is directly attached to the 1,2,4-oxadiazole ring was the most active among the 2-substituted chroman analogues, with EC50 = 254 ± 65 nM. Concerning the 5-subtituted chroman analogues, isoxazole derivative 29 exhibited the strongest activity (EC50 = 245 ± 38 nM). However, 29 was cytotoxic at concentrations higher than 1 μM, while the triazole analogue 24 (EC50 = 801 ± 229 nM), was non-toxic at all concentrations tested.