123593-66-8

Basic information

• Product Name: L-N-(tert-butoxycarbonyl)-4-benzyloxyphenylglycine
• Synonyms: L-N-(tert-butoxycarbonyl)-4-benzyloxyphenylglycine
• CAS NO: 123593-66-8
• Molecular Weight: 357.406
• Mol File: 123593-66-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-N-(tert-butoxycarbonyl)-4-benzyloxyphenylglycine(CAS DataBase Reference)
• NIST Chemistry Reference: L-N-(tert-butoxycarbonyl)-4-benzyloxyphenylglycine(123593-66-8)
• EPA Substance Registry System: L-N-(tert-butoxycarbonyl)-4-benzyloxyphenylglycine(123593-66-8)

Safety Data

• Hazardous Substances Data: 123593-66-8(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 69651-48-5 N-tert-butyloxycarbonyl-L-4-hydroxyphenylglycine 
• 914452-19-0 (S)-(4-benzyloxy-phenyl)-tert-butoxycarbonylamino-acetic acid benzyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 336877-72-6 L-2-[p-(benzyloxy)phenyl]glycine 
• 32462-30-9 (S)-hydroxyphenylglycine 

Downstream Products

• 914452-21-4 (S)-tert-butoxycarbonylamino-(4-hydroxy-phenyl)-acetic acid cyclopentyl ester 
• 914452-63-4 (S)-[4-(4-aminomethyl-phenoxy)-phenyl]-tert-butoxycarbonylamino-acetic acid cyclopentyl ester 
• 914452-64-5 (S)-tert-butoxycarbonylamino-{4-[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-phenoxy]-phenyl}-acetic acid cyclopentyl ester 
• 914452-20-3 (S)-(4-benzyloxy-phenyl)-tert-butoxycarbonylamino-acetic acid cyclopentyl ester 
• 127526-61-8 (8R,11R,14S)-8-Amino-18,19-dichloro-11-(4-hydroxy-phenyl)-5-iodo-4-methoxy-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3,5,7⁽²¹⁾,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester; hydrobromide 
• 126782-53-4 (S)-2-[(R)-2-[(R)-2-Benzyloxycarbonylamino-2-(4-hydroxy-3,5-diiodo-phenyl)-acetylamino]-2-(4-benzyloxy-phenyl)-acetylamino]-3-(3,5-dichloro-4-hydroxy-phenyl)-propionic acid methyl ester 
• 126782-54-5 (11R,14S)-8-Benzyloxycarbonylamino-11-(4-benzyloxy-phenyl)-18,19-dichloro-4-hydroxy-5-iodo-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3,5,7⁽²¹⁾,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester 
• 173383-07-8 (S)-[(S)-2-[(R)-2-Amino-2-(4-benzyloxy-phenyl)-acetylamino]-3-(3,5-dibromo-4-hydroxy-phenyl)-propionylamino]-(3,5-dimethoxy-phenyl)-acetic acid methyl ester 
• 173383-18-1 (S)-[(S)-2-[(R)-2-Amino-2-(4-benzyloxy-phenyl)-acetylamino]-3-(3,5-dichloro-4-hydroxy-phenyl)-propionylamino]-(3,5-dimethoxy-phenyl)-acetic acid methyl ester 
• 127526-60-7 (S)-2-[(R)-2-Amino-2-(4-benzyloxy-phenyl)-acetylamino]-3-(3,5-dichloro-4-hydroxy-phenyl)-propionic acid methyl ester; hydrochloride 
• 914452-62-3 {4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-phenyl}-(S)-tert-butoxycarbonylamino-acetic acid cyclopentyl ester 

Relevant articles and documents

HYDROXAMIC ACID DERVICATIVES AS INHIBITORS OF HDAC ENZYMATIC ACTIVITY

Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers: formula (I) wherein Y1 is a bond, -(C=O)-, -S(O2)-, -C(=O)O-, -OC(=O)-, -(C=O)NR3, -NR3(C=O)-, -S(O2)NR3-, -NR3S(O2)-, or -NR3(C=O)NR5-, wherein R3 and R5 are independently hydrogen or optionally substituted (C1-C6)alkyl, L1 is a divalent radical of formula -(Alk1)m(Q)n(Alk2)p- wherein m, n, p, AIk1, AIk2 and Q are as defined in the claims; z is O or 1 ; A represents an optionally substituted mono-, bi- or tri-cyclic carbocyclic or heterocyclic ring system; -[Linker]- represents a divalent linker radical; R is a radical of formula (X) or (Y); wherein R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R4 is hydrogen; or optionally substituted C1-C6 alkyl, C3-C7cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, heteroaryl(C1-C6 alkyl)-, -(C=O)R3, -(C=O)OR3, or -(C=O)NR3 wherein R3 is hydrogen or optionally substituted (C1-C6)alkyl, C3-C7 cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, or heteroary(C1-C6 alkyl)-; R41 is hydrogen or optionally substituted C1-C6 alkyl; and B is a monocyclic heterocyclic ring of 5 or 6 ring atoms wherein R1 is linked to a ring carbon adjacent the ring nitrogen shown, and ring B is optionally fused to a second carbocyclic or heterocyclic ring of 5 or 6 ring atoms in which case the bond shown intersected by a wavy line may be from a ring atom in said second ring.

New proctolin analogues modified by the novel D-or L-phenylglycine derivatives. Synthesis and biological studies

New analogues of insect neuromodulator proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH), modified in position 2 of the peptide chain by L-or D-phenylglycine and its 4-substituted derivatives were synthesized. For modification of proctolin a series of novel L-or D-phenylglycine derivatives H-Phg(4-NO2)-OH (1), Boc-Phg(4-NO2)-OH (2), Boc-Phg(4-Me2N)-OH (3), H-Phg(4-OBzl)-OH (4), Boc-Phg(4-OBzl)-OH (5), H-D-Phg(4-NO2)-OH (6), Boc-D-Phg(4-NO2,)-OH (7), Boc-D-Phg(4-Me2N)-OH (8), were used. The following proctolin analogues were synthesized: H-Arg-Phg-Leu-Pro-Thr-OH (9), H-Arg-D-Phg-Leu-Pro-Thr-OH (10), H-Arg-Phg(4-OH)-Leu-Pro-Thr-OH (11), H-Arg-D-Phg(4-OH)-Leu-Pro-Thr-OH (12), H-Arg-Phg(4-NO2)-Leu-Pro-Thr-OH (13), H-Arg-D-Phg(4-NO2)-Leu-Pro-Thr-OH (14), H-Arg-Phg(4-NH2)-Leu-Pro-Thr-OH (15), H-Arg-D-Phg(4-NH2)-Leu-Pro-Thr-OH (16), H-Arg-Phg(4-NMe2)-Leu-Pro-Thr-OH (17), H-Arg-D-Phg(4-NMe2)-Leu-Pro-Thr-OH (18). Myotropic activity of proctolin analogues 9-18 was assayed in vitro on the semi-isolated heart of the mealworm Tenebrio molitor and on the foregut of the locust Schistocerca gregaria. All analogues showed a weak or none activity.