1236069-51-4Relevant articles and documents
Enamine-based domino strategy for C-acylation/deacetylation of acetoacetamides: A practical synthesis of -keto amides
Angelov, Plamen
experimental part, p. 1273 - 1275 (2010/07/03)
A practical three-step route for C-acylation/deacetylation of acetoacetamides is described. Initial enamination of the acetoacetamides with Boc-monoprotected ethylenediamine provides β-enamino amides, which are acylated at the -carbon with excellent selectivity. The C-acylated derivatives undergo domino fragmentation in acidic media to give the corresponding β-keto amides accompanied by 2-methyl-4,5-dihydro-1H-imidazole. Georg Thieme Verlag Stuttgart.