123669-93-2Relevant articles and documents
Model studies for the synthesis of galbonolide B
Eshelby, James,Goessman, Matthias,Parsons, Philip J.,Pennicott, Lewis,Highton, Adrian
, p. 2994 - 2997 (2005)
The construction of the fourteen membered ring present in galbonolide B 1 is reported. The 10,11-diene system present in the southern portion of 1 has been constructed using an ester enolate rearrangement/silicon mediated fragmentation cascade, whilst the macrocycle has been synthesised following a Johnson rearrangement/mercury assisted ring closure protocol. The Royal Society of Chemistry 2005.
A formal stereoselective synthesis of (-)-maurenone
Yadav,Ravindar,Reddy
, p. 1957 - 1959 (2008/03/28)
An efficient formal synthesis of marine polypropionate (-)-maurenone is described. Highlights of the strategy include the utilization of a desymmetrization technique and the activation of the epoxide oxygen with a silyl triflate followed by intramolecular hydride transfer - a novel transformation. Georg Thieme Verlag Stuttgart.
Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
-
, (2008/06/13)
Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.