123673-33-6 Usage
Description
17(S)-HpDoHE, also known as 17-Hydroperoxydocosahexaenoic acid, is a bioactive lipid mediator derived from the metabolism of docosahexaenoic acid (DHA) in various human cells, including whole blood, leukocytes, glial cells, and mouse brain. It plays a crucial role in the production of specialized pro-resolving mediators (SPMs), which are essential for resolving inflammation and promoting tissue repair.
Uses
Used in Pharmaceutical Applications:
17(S)-HpDoHE is used as an anti-inflammatory agent for its ability to inhibit TNF-α-induced interleukin-1β expression in human glioma cells. This property makes it a potential candidate for the development of therapeutics targeting inflammation-related conditions.
Used in Neurological Applications:
In the context of neurological applications, 17(S)-HpDoHE is used as a neuroprotective agent due to its ability to inhibit TNF-α-induced leukocyte trafficking to the murine air pouch. This suggests that it may have potential applications in treating neuroinflammatory diseases and promoting brain health.
Used in Research and Development:
17(S)-HpDoHE is also used as a research tool for studying the metabolic pathways of docosahexaenoic acid and the role of SPMs in inflammation resolution and tissue repair. This can help scientists better understand the underlying mechanisms of various diseases and develop targeted therapies.
Used in Nutritional Supplements:
Given its anti-inflammatory and neuroprotective properties, 17(S)-HpDoHE may also be used as an ingredient in nutritional supplements aimed at promoting overall health and well-being, particularly in relation to brain and cognitive function.
Check Digit Verification of cas no
The CAS Registry Mumber 123673-33-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,6,7 and 3 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 123673-33:
(8*1)+(7*2)+(6*3)+(5*6)+(4*7)+(3*3)+(2*3)+(1*3)=116
116 % 10 = 6
So 123673-33-6 is a valid CAS Registry Number.
123673-33-6Relevant articles and documents
USE OF DOCOSATRIENES, RESOLVINS AND THEIR STABLE ANALOGS IN THE TREATMENT OF AIRWAY DISEASES AND ASTHMA
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Page/Page column 23/31, (2008/06/13)
The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA). Surprisingly, careful ;isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy EPA or DHA compounds having unique structural and physiological properties. The present invention therefore provides for many new useful therapeutic di- or tri-hydroxy derivatives of EPA or DHA (resolvins) that diminish, prevent, or eliminate inflammation or PMN migration, for example. The present invention also provides methods of use, methods of preparation, and packaged pharmaceuticals for use as medicaments for the compounds disclosed throughout the specification.
