123685-25-6Relevant articles and documents
Synthesis method of 2-bromo-3, 4-methylenedioxy-5-methoxybenzoic acid methyl ester
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, (2020/05/01)
The invention belongs to the field of chemical pharmacy, and specifically discloses a preparation method of 2-bromo-3, 4-methylenedioxy-5-methoxybenzoic acid methyl ester. The preparation method comprises the following steps: by taking gallic acid as a ra
An improved method for the synthesis of γ-DDB
Song, Chuanjun,Zhao, Peng,Hu, Zhiqiang,Shi, Shuai,Cui, Yanmei,Chang, Junbiao
supporting information; experimental part, p. 2297 - 2298 (2010/06/16)
A mild and efficient method for the synthesis γ-DDB has been developed through anhydride-linker assisted intramolecular Ullmann reaction. Highly regioselective bromination of differentially protected gallate was realized by virtue of the introduction of NBS.
Synthesis of unsymmetrical biphenyls as potent cytotoxic agents
Wu, Gang,Guo, Huan-Fang,Gao, Kun,Liu, Yi-Nan,Bastow, Kenneth F.,Morris-Natschke, Susan L.,Lee, Kuo-Hsiung,Xie, Lan
scheme or table, p. 5272 - 5276 (2009/05/07)
Twenty-six unsymmetrical biphenyls were synthesized and evaluated for cytotoxic activity against DU145, A549, KB and KB-Vin tumor cell lines. Three compounds 27, 35 and 40 showed very potent activity against the HTCL panel with an IC50 value range of 0.04-3.23 μM. In addition, fourteen active compounds were all more potent against the drug-resistant KB-Vin cell line than the parental KB cell line. Preliminary SAR analysis indicated that two bulky substituents on the 2,2′-positions of unsymmetrical biphenyl skeleton are necessary and crucial for in vitro anticancer activity, thus providing a good starting point to develop unsymmetrical biphenyls as novel anticancer agents.