1237714-78-1

Basic information

• Product Name: 4-(hydroxymethyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylic acid
• Synonyms: 4-(hydroxymethyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylic acid
• CAS NO: 1237714-78-1
• Molecular Weight: 287.195
• Mol File: 1237714-78-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(hydroxymethyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(hydroxymethyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylic acid(1237714-78-1)
• EPA Substance Registry System: 4-(hydroxymethyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylic acid(1237714-78-1)

Safety Data

• Hazardous Substances Data: 1237714-78-1(Hazardous Substances Data)

Upstream product

• 854015-40-0 4-methyl-5-(4-trifluoromethyl phenyl)-isoxazole-3-carboxylic acid ethyl ester 
• 1237714-73-6 ethyl 4-(bromomethyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate 

Downstream Products

• 1237715-31-9 N-cyclopentyl-4-(hydroxymethyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide 
• 1237715-80-8 (S)-4-(hydroxymethyl)-N-(3-methylbutan-2-yl)-5-(4-(trifluoromethyl)phenyl)-isoxazole-3-carboxamide 
• 1237714-83-8 4-(chloromethyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carbonyl chloride 
• 1304062-30-3 C₂₄H₃₀F₃N₃O₄ 
• 1237715-03-5 N-((1R,3S)-3-hydroxycyclohexyl)-4-((3,3,3-trifluoro-2-hydroxypropylamino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide 
• 1237714-95-2 C₂₃H₃₀F₃N₃O₄ 
• 1237715-09-1 C₂₃H₃₀F₃N₃O₄ 
• 1237714-99-6 4-((3-hydroxy-2,2-dimethylpropylamino)methyl)-N-((1R,3S)-3-hydroxycyclohexyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide 
• 1237715-27-3 N-((1R,3S)-3-hydroxycyclohexyl)-4-((2-methoxyethylamino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide 
• 1237715-05-7 N-((1R,3S)-3-hydroxycyclohexyl)-4-(((2-methoxyethyl)(methyl)amino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide 
• 1237715-21-7 N-((1R,3S)-3-hydroxycyclohexyl)-4-((methyl(2-(methylsulfonyl)ethyl)amino)-methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide 
• 1304062-38-1 C₂₄H₃₀F₃N₃O₄ 
• 1237715-15-9 N-((1R,3S)-3-hydroxycyclohexyl)-4-((isopropyl(methyl)amino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide 
• 1237715-23-9 4-((4-carbamoylpiperidin-1-yl)methyl)-N-((1R,3S)-3-hydroxycyclohexyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide 

Relevant articles and documents

Identification of potent, soluble, and orally active TRPV1 antagonists

Optimization of a water soluble, moderately potent lead series of isoxazole-3-carboxamides was conducted, affording a compound with the requisite balance of potency, solubility and physicochemical properties for in vivo use. Compound 8e was demonstrated to be efficacious in a rat model of inflammatory pain, following oral administration.

ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES

The present invention relates to isoxazole-3-carboxamide derivative having the general Formula I or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of said isoxazole-3-carboxamide deriv