123772-66-7

Basic information

• Product Name: Acetamide, N-(1-phenyl-2-propynyl)-
• CAS NO: 123772-66-7
• Molecular Formula: C11H11NO
• Molecular Weight: 173.214
• Mol File: 123772-66-7.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Acetamide, N-(1-phenyl-2-propynyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(1-phenyl-2-propynyl)-(123772-66-7)
• EPA Substance Registry System: Acetamide, N-(1-phenyl-2-propynyl)-(123772-66-7)

Safety Data

• Hazardous Substances Data: 123772-66-7(Hazardous Substances Data)

Upstream product

• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 75-05-8 acetonitrile 
• 60-35-5 acetamide 
• 100-52-7 benzaldehyde 
• 76651-92-8 1-phenyl-2-propynyl methanesulfonate 
• 75-36-5 acetyl chloride 
• 157022-35-0 1-phenylprop-2-yn-1-amine hydrochloride 
• 50874-15-2 1-phenylprop-2-ynyl-1-amine 

Downstream Products

• 226699-01-0 (S)-1-phenyl-2-propynylamine 
• 868701-79-5 (R)-N-(α-phenylpropargyl)acetamide 
• 226699-14-5 (R)-3-amino-3-phenylprop-1-yne 
• 688362-39-2 N-[(1R)-1-phenylprop-2-en-1-yl]benzamide 
• 688362-68-7 (R)-(+)-N-acetyl-1-phenylprop-2-enylamine 
• 244092-75-9 (1S)-1-phenyl-2-propen-1-amine 

Relevant articles and documents

Structure-based drug design, synthesis and biological assays of P. falciparum Atg3–Atg8 protein–protein interaction inhibitors

The proteins involved in the autophagy (Atg) pathway have recently been considered promising targets for the development of new antimalarial drugs. In particular, inhibitors of the protein–protein interaction (PPI) between Atg3 and Atg8 of Plasmodium falc

Base-Promoted Cycloisomerization for the Synthesis of Oxazoles and Imidazoles

Treatment of propargylamides or propargylamidines with cesium carbonate in DMSO results in the formation of the corresponding oxazoles or imidazoles in good yields. A large variety of substrates with various functional groups are tolerated. DFT study on a model substrate reveals that the reactions proceed via a sequence involving allene formation, intramolecular cyclization, and double-bond isomerization.

Synthesis of 1,2,3-Substituted Pyrroles from Propargylamines via a One-Pot Tandem Enyne Cross Metathesis-Cyclization Reaction

Enyne cross metathesis of propargylamines with ethyl vinyl ether enables the one-pot synthesis of substituted pyrroles. A series of substituted pyrroles, bearing alkyl, aryl, and heteroaryl substituents, has been synthesized in good yields under microwave irradiation. The reactions are rapid and procedurally simple and also represent a facile entry to the synthetically challenging 1,2,3-substituted pyrroles. The value of the methodology is further corroborated by the conversion of pyrroles into 3-methyl-pyrrolines and the derivatization of the 3-methyl-substituent arising from the metathesis reaction.