123860-84-4

Basic information

• Product Name: <8-lysine, 9-(1-aminocyclopropane-1-carboxylic acid)>vasopressin
• CAS NO: 123860-84-4
• Molecular Weight: 1082.27
• Mol File: 123860-84-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: <8-lysine, 9-(1-aminocyclopropane-1-carboxylic acid)>vasopressin(CAS DataBase Reference)
• NIST Chemistry Reference: <8-lysine, 9-(1-aminocyclopropane-1-carboxylic acid)>vasopressin(123860-84-4)
• EPA Substance Registry System: <8-lysine, 9-(1-aminocyclopropane-1-carboxylic acid)>vasopressin(123860-84-4)

Safety Data

• Hazardous Substances Data: 123860-84-4(Hazardous Substances Data)

Upstream product

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 61925-77-7 Boc-cysteine(4-Me-Bn) 
• 84677-06-5 (benzyloxycarbonylamino)cyclopropanecarboxylic acid 
• 47592-74-5 C₁₉H₂₇BrN₂O₆ 

Relevant articles and documents

SYNTHESIS AND PROPERTIES OF ANALOGUES OF VASOPRESSIN WITH 1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID IN POSITION 9

Solid phase methodology on benzhydrylamine resin was used for the synthesis of three analogues of vasopressin with non-coded amino acid, 1-aminocyclopropane-1-carboxylic acid, in position 9.Two analogues of lysine-vasopressin (8,Acc9>vasopressin (I) and Gly3-8,Acc9>vasopressin (II) and one analogue of arginine-vasopressin (8,Acc9>vasopressin (III)) have been synthesized.The dubious value of the biological activity of 8,D-Ala9>vasopressin was reevaluated and 8,L-Ala9>vasopressin was also synthesized and tested for the comparison.Differences in solution conformation of these two analogues were studied by 1H and 13C NMR spectroscopy.Biological activities of all analogues were either significantly lowered or almost completely eliminated.Analogues I-III were found to be completely inactive in analgesia and the CNS activities tested (active and passive avoidance).