123888-01-7

Basic information

• Product Name: 1,3-Bis-dicyclohexylamino-propan-2-ol
• CAS NO: 123888-01-7
• Molecular Weight: 418.707
• Mol File: 123888-01-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-Bis-dicyclohexylamino-propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Bis-dicyclohexylamino-propan-2-ol(123888-01-7)
• EPA Substance Registry System: 1,3-Bis-dicyclohexylamino-propan-2-ol(123888-01-7)

Safety Data

• Hazardous Substances Data: 123888-01-7(Hazardous Substances Data)

Upstream product

• 101-83-7 N-cyclohexyl-cyclohexanamine 
• 106-89-8 epichlorohydrin 
• 150389-77-8 1-Chloro-3-dicyclohexylamino-propan-2-ol 

Relevant articles and documents

New investigations of the reaction of epichlorohydrin with hindered amines: X-ray and NMR analyses

During the synthesis of a series of new antiarhythmic drugs, the reaction between epichlorohydrin and hindered amines was reinvestigated.With primary amines, 3-azetidinols were formed in fair yields.The X-ray structure elucidation of one of these compounds (1: P21/n, a=17.210, b=6.665, c=23.585, β=102.29, and R=0.064 for 2005 observed reflections) and NMR studies led to the conclusion that both the hydroxy group and the bulky nitrogen substituent are on the same side of the azetidine ring.With secondary amines, the reaction was very complex, leading to diaminodioxane, diamino alcohols, amino alcohol ethers, and one glycol.X-ray analysis and (1)H and (13)C NMR studies allowed complete assignments for all compounds.All but one exhibited a slow interconversion of the nitrogen visible in the (13)C NMR spectra. Key words: epichlorohydrin, hindered amines, azetidinol, adamantane, alkanol amines.